GluN2B protein and binding density in the hippocampus (dentate gyrus) of schizophrenia and control subjects. a. GluN2B protein density, normalised to β-actin, in the left and right hemisphere of schizophrenia (SZ) and control (CT) subjects. GluN2B was reduced in the left hemisphere of subjects with schizophrenia, compared to the left hemisphere of controls (−43%, p = 0.012) and compared to the right hemisphere of schizophrenia subjects (−40%, p = 0.023 ). *:p < 0.05. b. Representative blot showing GluN2B and β-actin protein expression in control (CT) and schizophrenia subjects (SZ) from the left and right hemisphere. GluN2B was identified as a single band at the expected molecular weight (175 kDa). c. [3H] Ifenprodil binding to GluN2B revealed no significant differences between schizophrenia (SZ) and control (CT) subjects, in the left or right hemisphere. Bars represent mean + SEM.