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Table 8 Base case and sensitivity analysis results

From: Long-acting olanzapine versus long-acting risperidone for schizophrenia in Spain – a cost-effectiveness comparison

OLAI versus RLAI

Incremental (discounted)

ICER (discounted)

Cost mean (SD)

LYs mean (SD)

QALYs mean (SD)

Relapses mean (SD)

Cost/QALY

Cost/relapse avoided

Cost/life year gained

Base case

-€2939.66 (300.83)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Revised OLAI dosing schedule (2 weekly starting dose & 4 weekly maintenance dose)

-€2810.58 (281.38)

0.04 0.021)

0.07 (0.018)

−0.41 (0.046)

Dominant

Dominant

Dominant

Discount Rate set to 0%

-€3068.23 (321.06)

0.04 (0.027)

0.08 (0.020)

−0.42 (0.049)

Dominant

Dominant

Dominant

Discount rate set to 6%

-€981.51 (125.16)

0.0001 (0.000)

0.0005 (0.000)

−0.42 (0.049)

Dominant

Dominant

Dominant

Relapse rate of OLAI equal to RLAI (0.176)

-€2513.30 (286.30)

0.04 (0.024)

0.05 (0.018)

−0.34 (0.044)

Dominant

Dominant

Dominant

Discontinuation of OLAI equal to RLAI (0.445)

-€1594.46 (324.59)

−0.003 (0.027)

−0.003 (0.019)

−0.07 (0.050)

€472796.00

Dominant

€491207.00

Maximum number of switches set to 5

-€2937.57 (314.19)

0.04 (0.023)

0.07 (0.017)

−0.42 0.050)

Dominant

Dominant

Dominant

Maximum number of switches set to 10

-€2947.24 (318.27)

0.04 (0.022)

0.07 (0.017)

−0.42 (0.052)

Dominant

Dominant

Dominant

Cost of routine management1 increased 30%

-€3527.51 (371.13)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Cost of routine management1 decreased 30%

-€2351.82 (232.74)

0.04(0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Yearly adverse event rate of OLAI equals RLAI

-€2878.91 (319.59)

0.04 (0.023)

0.09 (0.016)

−0.41 (0.052)

Dominant

Dominant

Dominant

Cost of administration increased 30%

-€3083.92 (303.46)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Cost of administration decreased 30%

-€2795.41 (298.37)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Cost of administration of OLAI equals RLAI

-€3392.17 (301.51)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Time Horizon 1 year

-€643.44 (116.98)

0.02 (0.004)

0.02 (0.003)

−0.11 (0.023)

Dominant

Dominant

Dominant

Time Horizon 2 years

-€1402.48 (168.63)

0.02 (0.009)

0.03 (0.007)

−0.21 (0.031)

Dominant

Dominant

Dominant

Time Horizon 3 years

-€2005.29 (224.89)

0.02 (0.015)

0.05 (0.011)

−0.29 (0.038)

Dominant

Dominant

Dominant

Time Horizon 4 years

-€2493.99 (267.06)

0.03 (0.019)

0.06 (0.014)

−0.36 (0.044)

Dominant

Dominant

Dominant

Time Horizon 10 years

-€4552.43 (513.34)

0.11 (0.057)

0.11 (0.040)

−0.72 (0.072)

Dominant

Dominant

Dominant

Time Horizon 15 years

-€5491.36 (746.04)

0.19 (0.089)

0.14 (0.059)

−0.96 (0.088)

Dominant

Dominant

Dominant

Time Horizon 20 years

-€6010.09 (985.99)

0.28 (0.118)

0.16 (0.076

−1.16 (0.111)

Dominant

Dominant

Dominant

Time Horizon 30 years

-€6184.28 (1387.21)

0.44 (0.172)

0.20 (0.104)

−1.41 (0.144)

Dominant

Dominant

Dominant

Utility tariffs increased 30%

-€2939.66 (300.83)

0.04 (0.025)

0.09 (0.024)

−0.42 (0.049)

Dominant

Dominant

Dominant

Utility tariffs decreased 30%

-€2939.66 (300.83)

0.04 (0.025)

0.05 (0.013)

−0.42 (0.049)

Dominant

Dominant

Dominant

Probability of doctors visit for adverse events 5%

-€2983.18 (269.74)

0.04 (0.023)

0.07 (0.019)

−0.43 (0.044)

Dominant

Dominant

Dominant

Probability of doctors visit for adverse events 15%

-€2824.75 (326.69)

0.04 (0.027)

0.07 (0.020)

−0.41 (0.050)

Dominant

Dominant

Dominant

Probability of switching treatment following doctors visit for adverse events 5%

-€2940.17 (303.80)

0.04 (0.024)

0.07 (0.017)

−0.42 (0.051)

Dominant

Dominant

Dominant

Probability of switching treatment following doctors visit for adverse events 25%

-€2849.86 (334.18)

0.04 (0.024)

0.07 (0.018)

−0.41 (0.054)

Dominant

Dominant

Dominant

Cost of OLAI increased 25%

-€152.19 (302.58)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Cost of OLAI decreased 25%

-€5727.14 (304.63)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Branded drug costs decreased 7.5%

-€2899.05 (296.94)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Cost of concomitant medication increased 25%

-€2934.53 (302.95)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

Cost of concomitant medication decreased 25%

-€2944.80 (298.74)

0.04 (0.025)

0.07 (0.019)

−0.42 (0.049)

Dominant

Dominant

Dominant

  1. 1Including the variables cost of schizophrenia management, inpatient cost of relapse management, outpatient cost of relapse management.
  2. SD = Standard deviation.