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Table 3 2 × 2 ANCOVA (group x genotype) matched for age, gender and protocol

From: The BDNFp.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

  MNI eCoordinates   
Brain region x y z Brodmann Area Cluster Size (Voxels) Z-statistic Cluster p-value
Ancova analyses:
Main effect of group
Left lateral prefrontal cortex −43 48 −17 11 125 3.64 <0.001
Main effect of genotype
Left lateral prefrontal cortex −43 48 −17 11 129 3.66 <0.001
Left occipital lobe −32 −88 3 19 58 3.52 <0.001
Main effect of CTQ total score
Left parahippocampal gyrus −26 −24 −25 35 958 4.16 <0.001
Genotype x alcohol group interaction
Left lateral prefrontal cortex −43 48 −17 11 32 3.33 <0.001
CTQ total score x genotype interaction
Fusiform gyrus 39 −59 −21 NAf 890 3.69 <0.001
POST-HOC t-tests g:
Genotype post-hoc t-test: Val/Val > Val/Met + Met/Met
Left lateral prefrontal cortex −40 12 28 9 29 3.24 <0.001
Within-group genotype t-test (AUD): Val/Val > Val/Met + Met/Met
Left lateral prefrontal cortex −38 13 28 9 17 3.18 <0.001
Between-group genotype t-test (Val/Val): HC > AUD
Left lateral prefrontal cortex −20 23 −30 11 332 3.88 <0.001
Within-group CTQ t-test ( Val/Met + Met/Met ): low > high CTQ
Middle Occipital gyrus −17 −93 14 18 708 4.78 <0.001
Within-group CTQ t-test (Val/Val): low > high CTQ
Middle frontal gyrus −27 25 −18 NA 708 4.06 <0.001
  1. eMNI = Montreal Neurological Institute CoordinateSs. fNot applicable. gBesides the CTQ t-tests, all post-hoc t-tests were analysed with CTQ as a covariate of interest.