TY - JOUR AU - Brambilla, Francesca AU - Amianto, Federico AU - Dalle Grave, Riccardo AU - Fassino, Secondo PY - 2014 DA - 2014/12/24 TI - Lack of efficacy of psychological and pharmacological treatments of disorders of eating behavior: neurobiological background JO - BMC Psychiatry SP - 376 VL - 14 IS - 1 AB - Treatments of eating disorders result too often in partial psychological and physical remission, chronicization, dropout, relapse and death, with no fully known explanations for this failure. In order to clarify this problem, we conducted three studies to identify the biochemical background of cognitive-behavioural psychotherapy (CBT), individual psychology brief psychotherapy (IBPP), and psychotherapy-pharmacotherapy with CBT + olanzapine in anorexics (AN) and bulimics (BN) by measuring the levels of plasma homovanillic acid (HVA) for dopamine secretion, plasma 3-methoxy-4-hydroxy-phenylglycol (MHPG) for noradrenalin secretion, and platelet [3H]-Paroxetin-binding Bmax and Kd for serotonin transporter function. The data were then compared with psychopathological and physical alterations. SN - 1471-244X UR - https://doi.org/10.1186/s12888-014-0376-7 DO - 10.1186/s12888-014-0376-7 ID - Brambilla2014 ER -