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Table 2 Outcome measures for Intent-to-Treat sample in the first 12 months (N = 5)

From: Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study

 

Baseline (surgery)

3 months

6 months

9 months

12 months

Repeated measures ANOVA

Variable

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

F

p

HDRS-17

23.0 (±2.0)

14.8 (±6.9)

15.2 (±8.6)

15.0 (±9.5)

14.6 (±8.7)

1.120

.382

MADRS

31.4 (±5.6)

18.8 (±9.9)

19.6 (±13.1)

19.2 (±14.5)

18.8 (±13.3)

1.496

.250

CGI-S

5.6 (±0.5)

4.0 (±1.6)

4.2 (±1.1)

3.6 (±2.1)

3.4 (±2.3)

2.429

.090

SF-36 physical summary

42.7 (±7.4)

45.8 (±2.9)

46.3 (±7.1)

43.9 (±2.7)

46.6 (±4.4)

.416

.794

SF-36 mental summary

25.5 (±17.2)

31.7 (±20.4)

31.3 (±15.2)

26.6 (±11.1)

31.7 (±18.4)

.245

.909

  1. HDRS-17: 17-item Hamilton Depression Rating Scale; MADRS: Montgomery Asberg Depression Rating Scale; CGI-S: Clinical Global Impression – Severity of Illness.