Neuropsychological domains*

Studies¹

Effect size²

SE ³

N
^{
4
}

Lower limit
^{
5
}

Upper limit
^{
6
}

Q
^{
7
}

p f
or Q
^{
8
}

Z
^{
9
}

p
for Z
^{
10
}

I²
^{
11
}

Fail safe N
^{
12
}


INFANTS
            
Cognition

4

0.23

0.09

251

0.05

0.41

2.97

0.56

2.54

0.01

0.00

4

Psychomotor

4

0.43

0.09

251

0.25

0.60

5.36

0.25

4.65

0.00

25.41

25

Behavior

3

0.44

0.12

145

0.20

0.67

1.59

0.45

3.68

0.00

0.00

8

PRESCHOOL CHILDREN
            
Cognition

3

0.33

0.15

224

0.03

0.63

2.19

0.53

2.18

0.03

0.00

0

Psychomotor

3

0.58

0.15

224

0.28

0.88

6.36

0.09

3.78

0.00

52.84

31

Behavior*1

2

1.31

0.33

160

0.67

1.95

5.96

0.02

3.99

0.00

83.21

np

 ^{1}= Number of studies used to calculate effect size, ^{2}= Cohen’s d effect size, ^{3}= Standard Error, ^{4}=Total number of subjects in opioid exposed cohort ,^{5}= Lower limit of the 95% confidence interval for the effect size,^{6}= Upper limit of the 95% confidence interval for the effect size, ^{7}= Q statistic: A test of homogeneity, ^{8}= Probability that Q statistics significantly diff than 0, ^{9}= One sample Z Statistic, ^{10}= Probability that Z Statistics, is significantly diff than 0, ^{11}= I² statistics,^{12}= Fail Safe N: a measure of publication bias, n/p= not possible since one needs more than 2 studies to perform this analysis, * All neuropsychological domains had fixed effects model employed except *1 where a random effect model was employed.