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Table 1 Effect sizes and associated statistics for neurobehavioral domains in intrauterine opioid exposed infants and preschool children compared to others who have no history of intrauterine opioid exposure during pregnancy

From: Erratum: Neurobehavioral consequences of chronic intrauterine opioid exposure in infants and preschool children: a systematic review and meta-analysis

Neuropsychological domains* Studies¹ Effect size² SE ³ N 4 Lower limit 5 Upper limit 6 Q 7 p f or Q 8 Z 9 p for Z 10 11 Fail safe N 12
INFANTS             
Cognition 4 0.23 0.09 251 0.05 0.41 2.97 0.56 2.54 0.01 0.00 4
Psychomotor 4 0.43 0.09 251 0.25 0.60 5.36 0.25 4.65 0.00 25.41 25
Behavior 3 0.44 0.12 145 0.20 0.67 1.59 0.45 3.68 0.00 0.00 8
PRESCHOOL CHILDREN             
Cognition 3 0.33 0.15 224 0.03 0.63 2.19 0.53 2.18 0.03 0.00 0
Psychomotor 3 0.58 0.15 224 0.28 0.88 6.36 0.09 3.78 0.00 52.84 31
Behavior*1 2 1.31 0.33 160 0.67 1.95 5.96 0.02 3.99 0.00 83.21 np
  1. 1= Number of studies used to calculate effect size, 2= Cohen’s d effect size, 3= Standard Error, 4=Total number of subjects in opioid exposed cohort ,5= Lower limit of the 95% confidence interval for the effect size,6= Upper limit of the 95% confidence interval for the effect size, 7= Q statistic: A test of homogeneity, 8= Probability that Q statistics significantly diff than 0, 9= One sample Z Statistic, 10= Probability that Z Statistics, is significantly diff than 0, 11= I² statistics,12= Fail Safe N: a measure of publication bias, n/p= not possible since one needs more than 2 studies to perform this analysis, * All neuropsychological domains had fixed effects model employed except *1 where a random effect model was employed.