Oxidant/antioxidant imbalance is an inherent feature of depression

BMC Psychiatry

Table 4 Comparison of expression of the analysed genes on the mRNA level and protein level in the affected from the ED-I and rDD group

Variable	ED-I	rDD	Mann–Whitney U test
Variable	M (SD)	M (SD)	Z	p
MnSOD	0.529	0.548	0.266	0.791
mRNA (2^-ΔΔct)	(0.189)	(0.158)
MnSOD	172.26	176.83	0.283	0.776
protein (pg/ml)	(72.78)	(60.97)
MPO	0.319	0.314	−0.531	0.596
mRNA (2^-ΔΔct)	(0.037)	(0.041)
MPO	311.16	307.91	−0.271	0.786
protein (ng/ml)	(38.08)	(40.96)
COX-2	0.242	0.235	−0.806	0.421
mRNA (2^-ΔΔct)	(0.039)	(0.038)
COX-2	116.47	113.79	−0.483	0.628
protein (ng/ml)	(24.84)	(24.71)
iNOS	0.103	0.101	−0.086	0.931
mRNA (2^-ΔΔct)	(0.023)	(0.022)
iNOS	21.01	20.56	0.044	0.964
protein (U/ml)	(8.66)	(8.02)

ED-I – first episode of depression, rDD – recurrent depressive disorder, MnSOD – manganese superoxide dismutase, MPO – myeloperoxidase, COX-2 – cyclooxygenase-2, iNOS – cytokine-inducible nitric oxide synthase, M – mean, SD – standard deviation.

ISSN: 1471-244X