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Table 4 Comparison of expression of the analysed genes on the mRNA level and protein level in the affected from the ED-I and rDD group

From: Oxidant/antioxidant imbalance is an inherent feature of depression

Variable ED-I rDD Mann–Whitney U test
M (SD) M (SD) Z p
MnSOD 0.529 0.548 0.266 0.791
mRNA (2-ΔΔct) (0.189) (0.158)   
MnSOD 172.26 176.83 0.283 0.776
protein (pg/ml) (72.78) (60.97)   
MPO 0.319 0.314 −0.531 0.596
mRNA (2-ΔΔct) (0.037) (0.041)   
MPO 311.16 307.91 −0.271 0.786
protein (ng/ml) (38.08) (40.96)   
COX-2 0.242 0.235 −0.806 0.421
mRNA (2-ΔΔct) (0.039) (0.038)   
COX-2 116.47 113.79 −0.483 0.628
protein (ng/ml) (24.84) (24.71)   
iNOS 0.103 0.101 −0.086 0.931
mRNA (2-ΔΔct) (0.023) (0.022)   
iNOS 21.01 20.56 0.044 0.964
protein (U/ml) (8.66) (8.02)   
  1. ED-I – first episode of depression, rDD – recurrent depressive disorder, MnSOD – manganese superoxide dismutase, MPO – myeloperoxidase, COX-2 – cyclooxygenase-2, iNOS – cytokine-inducible nitric oxide synthase, M – mean, SD – standard deviation.