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Table 1 Characteristics of cases (patients with first record of pulmonary embolism) and matched controls at index date

From: Antipsychotic drug exposure and risk of pulmonary embolism: a population-based, nested case–control study

 

Cases (n = 232)

Controls (n = 4353)

P value*

Mean age ± SD

77.1 ± 13.5

76.9 ± 13.7

0.798

  Age ≥ 65

194 (83.6%)

3,610 (82.9%)

 

  Age < 65

38 (16.4%)

743 (17.1%)

 

Women

157 (67.7%)

2,950 (67.8%)

0.975

Men

75 (32.3%)

1,403 (32.2%)

 

Hospitalization§

   

  Mental disorders

72 (31.0%)

468 (10.8%)

<.001

  Coronary heart disease

22 (9.5%)

114 (2.6%)

<.001

  Heart failure

21 (9.1%)

118 (2.7%)

<.001

  Stroke

12 (5.2%)

108 (2.5%)

0.012

  Chronic liver disease

5 (2.2%)

19 (0.4%)

0.000

  Parkinson’s disease

32 (13.8%)

481 (11.0%)

0.197

  Chronic renal disease

20 (8.6%)

90 (2.1%)

<.001

Drug use§

   

  Lithium

5 (2.2%)

84 (1.9%)

0.808

  Statins

39 (16.8%)

744 (17.1%)

0.912

  NSAIDs

67 (28.9%)

1,036 (23.8%)

0.078

  Antiplatelet treatment

123 (53.0%)

1,981 (45.5%)

0.025

  Anti-diabetic

34 (14.7%)

613 (14.1%)

0.807

  Antihypertensive agents

155 (66.8%)

2,608 (59.9%)

0.036

  1. *chi-square statistics.
  2. § in the 12 months preceding index date.
  3. NSAIDs = non-steroidal anti-inflammatory drugs.