Analyzing pathways from childhood maltreatment to internalizing symptoms and disorders in children and adolescents (AMIS): a study protocol

Table 2 Assessment of child neurobiological and genetic factors

Variables	Source	Measure	Assessment	Age groups		Samples
Neurobiological factors				4-8	9-14
Chronic stress exposure	● Hair	● Cortisol	Normal appointment	x	x	1-4
Genomic mechanisms	● Plasma/Saliva	● Steroid metabolomics	Trier Social Stress Test for Children (TSST-C)		x	2^a,3^a
Genomic mechanisms	● Plasma/Saliva	● Methylation	Trier Social Stress Test for Children (TSST-C)		x	2^a,3^a
Stress response regulation	● Saliva	● Saliva cortisol	TSST-C		x	2^a,3^a
	● Plasma	● Blood cortisol
	● Plasma	● α-Amylase
Genomic factors
Susceptibility genes	● Saliva/Plasma	● Focus on HPA-axis-related genes	Normal appointment	x	x	1-4

ISSN: 1471-244X