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Table 2 MTR-, ADC- and FA-map differences in patients with OCD compared to healthy control subjects

From: Obsessive-compulsive disorder is a heterogeneous disorder: evidence from diffusion tensor imaging and magnetization transfer imaging

Regions Cluster size t-value MNI-space P-value
    x y z SVC
Decreased regional FA in OCD patients compared with controls
Left sub-gyral WM 656 5.52 −39 −4 −19 0.001
Left medial frontal gyrus WM 472 4.95 −18 46 12 0.003
Left superior frontal gyrus WM 103 3.88 −11 58 22 0.035
Right inferior frontal gyrus WM 45 3.83 50 31 −9 0.038
Right superior temporal gyrus WM 75 3.77 60 −16 8 0.043
Right inferior frontal gyrus (BA 47) GM 74 3.97 56 22 −6 0.028
Right cuneus (BA 18) GM 88 4.10 13   10 0.021
Right postcentral gyrus (BA 3) GM 121 3.76 53 −17 39 0.044
Increased ADC-maps in patients with OCD compared with controls
Left sub-gyral WM 166 4.02 −37 −1 −23 0.024
Left inferior frontal gyrus WM 99 4.00 −36 26 −5 0.025
Left middle frontal gyrus WM 77 4.36 −27 20 43 0.010
Left middle occipital gyrus WM 74 3.95 −46 −70 −4 0.026
Left parahippocampal gyrus WM 61 4.13 −29 −29 −18 0.019
Right superior frontal gyrus (BA 10) GM 931 5.08 21 66 11 0.002
Left middle temporal gyrus (BA 21) GM 70 4.02 −62 −2 −3 0.024
Left inferior frontal gyrus (BA 47) GM 33 3.74 −28 17 −13 0.043
Increased MTR maps in OCD patients compared with controls
Left middle frontal gyrus 125 4.48 −39 24 43 0.008
Right inferior frontal gyrus (BA40) 58 4.46 51 25 5 0.008
  1. Cluster size = number of voxels; x,y,z = Coordinates (in mm) of significant local maxima are given for information in MNI space (Montreal Neurological Institute, http://www.bic.mni.mcgill.ca). BA: Brodmann area. For regions where an effect was hypothesized a small volume correction (SVC) was performed. P values are given after family wise error (FWE) correction for the particular volume