Hypoglutamatergic state is associated with reduced cerebral glucose metabolism in anti-NMDA receptor encephalitis: a case report

Table 1 Magnetic resonance spectroscopy (¹H-MRS) results

	Left prefrontal cortex		Right prefrontal cortex
	Metabolite concentration (in IU) (CRLB)	Metabolite ratio (/Cre)	Metabolite concentration (in IU) (CRLB)	Metabolite ratio(/Cre)
Glx	5.673 (12 %)	1.129	7.424 (8 %)	1.576
Cre	5.023 (3 %)	1.0	4.710 (3 %)	1.0
t-Cho	1.238 (3 %)	0.246	1.217 (3 %)	0.258
NAA + NAAG	6.783 (3 %)	1.350	5.802 (3 %)	1.232
mI	3.815 (5 %)	0.760	3.295 (5 %)	0.699

The MRS spectrum from the left prefrontal cortex shows lower concentrations of Glx compared with the opposite side. Glutamatergic hypometabolism correlated with a distinct hypometabolism in FDG-PET in this region; TR = 3000; TE = 30; NS = 64; voxel size = 8.0 mL. Abbreviations: CRLB = Cramér-Rao lower bounds; IU = Institutional Units; Glx = glutamate + glutamate; Cre = creatine; t-Cho = phosphorylcholine + glycerophosphorylcholine; NAA + NAAG = N-acetylaspartate + N-acetyl-aspartyl glutamate; mI = myo-inositol

ISSN: 1471-244X