Table 4 Regression models with associated predictors for change in Montgomery and Asberg Depression Rating Scale (MADRS) score, response and remission as dependent variable (n = 122)
Linear mixed model (Change in MADRS score as dependent variable) | Logistic regression model for hierarchical data (Response as dependent variable) | Logistic regression model for hierarchical data (Remission as dependent variable) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bivariate analysis | Multivariable analysis | Bivariate analysis | Multivariable analysis | Bivariate analysis | Multivariable analysis | |||||||
Coefficient (95 % CI2) | p-value | Coefficient (95 % CI2) | p-value | OR3 (95 % CI2) | p-value | OR3 (95 % CI2) | p-value | OR3 (95 % CI2) | p-value | OR3 (95 % CI2) | p-value | |
MMSE | 0.49 (0.03;0.96) | 0.038* | 1.10 (0.98;1.23) | 0.094 | 1.05 (0.95;1.17) | 0.337 | ||||||
HADS-A | 0.14 (−0.25;0.52) | 0.482 | 0.97 (0.88;1.06) | 0.443 | 0.90 (0.83;0.99) | 0.024* | 0.93 (0.84;1.03) | 0.150 | ||||
Number of drugs | 0.10 (−0.47;0.68) | 0.720 | 0.90 (0.79;1.03) | 0.117 | 0.95 (0.84;1.08) | 0.445 | ||||||
Previous depressive episode (s) (Yes as 01) | −0.09 (−3.80;3.63) | 0.964 | −2.01 (−7.09;3.07) | 0.436 | 1.28 (1.28;3.14) | 0.581 | 3.30 (1.41;7.68) | 0.006* | 4.61 (1.64;13.01) | 0.004* | ||
IADL score | 2.11 (−4.81;9.04) | 0.547 | 0.60 (−7.99;6.79) | 0.873 | 2.67 (0.56;12.79) | 0.217 | 5.36 (1.06;27.27) | 0.043* | 3.82 (0.63;23.20) | 0.144 | ||
Diagnosis of dementia (No diagnosis as 01) | −8.26 (−14.19;-2.33) | 0.007* | −9.03 (−15.40;2.64) | 0.006* | 0.27 (0.07;1.05) | 0.058 | 0.25 (0.06;1.03) | 0.055 | 0.21 (0.04;1.08) | 0.061 | 0.11 (0.02;0.73) | 0.023* |
Age at onset of first lifetime depressive episode (<60 years as 01) | 1.10 (−2.29;4.48) | 0.523 | 3.35 (− 1.28;7.99) | 0.154 | 1.79 (0.80;4.00) | 0.157 | 2.50 (1.17;5.36) | 0.019* | ||||
Duration of current depressive episode (≤12 weeks as 01) | −2.61 (−6.22;1.00) | 0.154 | −2.40 (−6.14;1.35) | 0.207 | 0.83 (0.35;1.96) | 0.667 | 0.56 (0.24;1.33) | 0.184 | 0.50 (0.20;1.28) | 0.147 | ||
GMHR (Very good/good as 01) | −2.23 (−5.67;1.21) | 0.202 | −1.38 (−4.90;2.13) | 0.436 | 0.35 (0.15;0.79) | 0.012* | 0.38 (0.16;0.90) | 0.029* | 0.52 (0.24;1.11) | 0.091 | ||
Depression with psychosis according ICD-10 (no as 01) | 3.42 (−2.68;9.52) | 0.269 | 3.42 (−2.86;9.69) | 0.283 | 1.05 (0.24;4.62) | 0.946 | 1.68 (0.42;6.70) | 0.458 | ||||
Age | −0.15 (−0.41;0.11) | 0.258 | −0.28 (−0.57;0.006) | 0.055 | 1.06 (0.99;1.14) | 0.064 | 1.04 (0.97;1.12) | 0.232 | 1.01 (0.95;1.07) | 0.731 | 1.00 (0.93;1.07) | 0.983 |
Years of education | 0.06 (−0.53;0.64) | 0.850 | -0.19 (-0.78;0.41) | 0.533 | 0.91 (0.80;1.04) | 0.160 | 0.92 (0.80;1.05) | 0.218 | 0.95 (0.84;1.08) | 0.438 | 0.94 (0.82;1.09) | 0.413 |
Gender (Female as 01) | 2.58 (−1.26;6.42) | 0.187 | 1.82 (−2.09;5.73) | 0.357 | 0.71 (0.29;1.74) | 0.449 | 0.81 (0.31;2.15) | 0.675 | 1.16 (0.49;2.75) | 0.733 | 0.96 (0.36;2.58) | 0.931 |
Marital status (Not-single as 01) | −2.28 (−5.69;1.14) | 0.189 | −2.25 (−5.84;1.33) | 0.216 | 1.20 (0.54;2.69) | 0.656 | 1.01 (0.42;2.40) | 0.989 | 1.24 (0.58;2.66) | 0.580 | 0.86 (0.34;2.17) | 0.752 |
Days of stay in hospital | −0.02 (−0.06;0.01) | 0.216 | −0.03 (−0.07;0.004) | 0.083 | 0.99 (0.98;1.00) | 0.061 | 0.99 (0.98;1.00) | 0.042* | 0.989 (0.979;0.999) | 0.026* | 0.987 (0.976;0.997) | 0.014* |