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Table 2 Lean muscle mass (locomotion, stabilization/posture) difference (95 % confidence interval [CI]) between elevated depressive symptoms status (EDS, CES-D ≥ 16 and/or antidepressant use)a

From: Sex and race/ethnic disparities in the cross-sectional association between depressive symptoms and muscle mass: the Multi-ethnic Study of Atherosclerosis

Stratification

Adjustment Models (Difference [95 % CI])b

Model 1

Model 2

Model 3

Model 4

ALL LEAN MUSCLE MASS (in cm2, N = 1605)

−17.8 (−26.9, −8.8)*

−7.6 (−14.9, −0.3)*

−18.9 (−27.7, −10.0)*

−8.0 (−15.2, −0.7)*

LOCOMOTION

All (in cm2, N = 1,605)

−6.2 (−9.7, −2.7)*

−2.5 (−5.3, 0.4)

−6.5 (−9.9, −3.1)*

−2.4 (−5.2, 0.4)

By Sex (in cm2)

 Women (n = 823, 51.3 %)

−1.8 (−5.6, 1.9)

−0.3 (−3.9, 3.2)

−1.8 (−5.5, 1.9)

−0.3 (−3.8, 3.2)

 Men (n = 782, 48.7 %)

−5.4 (−10.2, −0.5)

−6.1 (−10.7, −1.5)*

−5.3 (−10.0, −0.5)*

−5.9 (−10.5, −1.4)*

By Race/ethnicity (in cm2)

 White (n = 667, 41.6 %)

−5.1 (10.3, 0.1)

−0.4 (−4.6, 3.9)

−5.7 (−10.8, −0.7)*

−0.6 (−4.8, 3.6)

 Chinese (n = 232, 14.5 %)

−14.5 (−24.6, −4.4)*

−9.8 (−18.0, −1.6)*

−15.4 (−25.3, −5.6)*

−10.2 (−18.3, −2.1)*

 Black (n = 315, 19.6 %)

−1.6 (−10.5, 7.2)

−0.2 (−7.4, 7.0)

−2.1 (−10.7, 6.5)

−0.2 (−7.3, 6.9)

 Hispanic (n = 391, 24.4 %)

−5.4 (−11.8, 0.9)

−3.9 (−9.0, 1.3)

−4.7 (−10.9, 1.4)

−3.2 (−8.3, 1.9)

STABILIZATION/POSTURE

All (in cm2, N = 1605)

−11.6 (−18.4, −4.8)*

−5.1 (−11.4, 0.8)

−12.4 (−19.1, −5.7)*

−5.5 (−11.5, 0.4)

  1. aSignificant interaction at a p-value < 0.20: Locomotion Muscles: (1) Ethnic minority vs. White = 0.19: Chinese vs. White = 0.04; Black vs. White = 0.93; Hispanic vs. White = 0.43; (2) by sex = 0.05; Stabilization Muscles: (1) Ethnic minority vs. White = 0.81: Chinese vs. White = 0.87; Black vs. White = 0.33; Hispanic vs. White = 0.76; (2) by sex = 0.22
  2. bModel 1 = Adjusted for age, height, BMI (main effects for sex or race/ethnicity were evaluated in this model when assessing interaction for sex or race/ethnicity, respectively; otherwise they were included in model 2); Model 2 = Adjusted for Model 1, sex, race/ethnicity, marital status, education, income, study site, and comorbidities (diabetes, cancer, hypertension); Model 3 = Adjusted for Model 1, inflammatory markers (IL-6, CRP), other health behaviors (alcohol consumption per week, pack-years of smoking, and total intentional exercise); Model 4 = Fully-adjusted
  3. *Significant at a p-value < 0.05 for main effects