Contribution of estradiol levels and hormonal contraceptives to sex differences within the fear network during fear conditioning and extinction

Table 3 Summary table for subgroup comparisons throughout the different experimental phases of the paradigm

	Unconditioned	Conditioning	Extinction	Recall
Insular cortex	M > OC	HE > M	HE > M	HE > M
Insular cortex	M > OC	HE > OC	HE > LE	HE > M
MCC	n.s.	HE > M	n.s.	HE > M
MCC	n.s.	HE > OC	n.s.	HE > M
rACC	n.s.	n.s.	HE > M	n.s.
Amygdala	n.s.	HE > M	n.s.	n.s.
		HE > LE
		HE > OC
Hypothalamus	n.s.	HE > M	n.s.	n.s.
Hypothalamus	n.s.	HE > OC	n.s.	n.s.
Hippocampus	M > OC	n.s.	n.s.	n.s.

‘Unconditioned’ refers to the contrast Shock vs. CS- offset during fear conditioning, ‘Conditioning’ refers to the CS+ vs. CS- contrast during fear conditioning, ‘Extinction’ refers to the late CS+ vs. late CS- of the extinction training, and ‘Recall’ refers to the early CS + E trials vs. early CS + U trials of the extinction recall test. (n.s. = no significant main effect of group)

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