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Table 1 Demographic and clinical characteristics

From: Distinguishing bipolar and major depressive disorders by brain structural morphometry: a pilot study

  BD (n = 16) MDD (n = 19) HC (n = 29) F/χ2/t-scores p-value
Male % (male/female) 37.5 % (6/10) 42.1 % (8/11) 37.9 % (11/18) χ2 = 0.11 0.95
Right-handed % 100 100 100 F(2) = 0.00 1.00
Age (in years) 26.3 (7.9) 30.0 (8.9) 27.1 (8.4) F(2) = 1.02 0.37
Education (in years) 15.1 (1.8) 14.4 (3.2) 14.9 (2.5) F(2) = 0.42 0.66
IQ estimates 116.9 (16.1) 116.7 (13.1) 120.4 (12.7) F(2) = 0.54 0.59
Intracranial Volume (ICV, cm3) 1295 (207) 1439 (195) 1372 (201) F(2) = 2.24 0.12
Medication History
 Untreated (N) 5 8 / / /
 Antidepressants (N) 5 11 / / /
 Antipsychotics (N) 8 2 / / /
 CPZ (mg) 226.2 (327.4) 38.3 (40.1) / / /
 Atypical (N) 8 1 / / /
 Typical (N) 0 1 / / /
 Trihexyphenidyl (N) 1 0 / / /
 Antianxiety (N) 2 3 / / /
 Lithium (N) 2 0 / / /
 Valproate (N) 2 0 / / /
 Lithium + Valproate (N) 1 0 / / /
Clinical Information
 Duration of illness (in years)* 5.2 (4.8) 4.9 (3.5) / t = -0.23 0.82
 HAMD-17* 9.9 (4.5) 11.1 (4.3) / t = 0.77 0.45
 YMRS* 6.40 (6.9) 2.2 (2.6) / t = -2.35 0.03
  1. Abbreviations: MDD Major Depressive Disorder, BD Bipolar Disorder, HC Health Controls, YMRS Young Mania Rating Scale, HAMD-17 Hamilton rating scale for Depression-17 items, N number of patients
  2. *p-values were generated from comparisons between the BD and MDD groups (t-tests, two-tailed)
  3. Chi-squared test was used in gender. One-way analyses of variance (ANOVA) were used in age, IQ estimates, handedness, education and ICV