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Table 3 Differences in regions-of-interest (ROIs) between patients with bipolar disorder and patients with major depressive disorder after controlling for age, IQ and total intracranial volume

From: Distinguishing bipolar and major depressive disorders by brain structural morphometry: a pilot study

  ROI df Mean in BD Mean in MDD t p p.adj (FDR)
Cortical (area.pial) L bankssts 32.09 2.80E-07 2.31E-07 1.73 0.09 0.09
L precentral 29.01 1.33E-06 1.11E-06 1.83 0.08 0.09
L inferiorparietal 32.28 1.32E-06 1.09E-06 1.91 0.07 0.09
L superiorparietal 28.98 1.53E-06 1.17E-06 2.45 0.02 0.05
L precuneus 28.98 1.10E-06 8.56E-07 2.41 0.02 0.05
R middletemporal 27.53 9.76E-07 7.59E-07 2.43 0.02 0.05
Subcortical (volume) L thalamus 25.72 1.99E-06 1.60E-06 1.95 0.06 0.08
L caudate nucleus 28.90 9.85E-07 8.13E-07 1.84 0.08 0.08
L putamen 26.15 1.70E-06 1.36E-06 1.99 0.06 0.08
L hippocampus 23.37 1.20E-06 9.15E-07 2.42 0.02 0.05
L amygdala 25.70 4.95E-07 3.83E-07 2.68 0.01 0.05
L nucleus accumbens 25.27 1.64E-07 1.17E-07 2.52 0.02 0.05
R thalamus 25.07 1.94E-06 1.60E-06 1.89 0.07 0.08
R caudate nucleus 27.58 1.01E-06 8.17E-07 1.89 0.07 0.08
R putamen 26.37 1.65E-06 1.31E-06 2.07 0.05 0.08
R hippocampus 24.94 1.24E-06 9.56E-07 2.57 0.02 0.05
R amygdala 27.23 5.03E-07 3.96E-07 2.44 0.02 0.05
R nucleus accumbens 28.10 1.84E-07 1.36E-07 2.47 0.02 0.05
  1. A ratio of each ROI was calculated to control for the individual variations of ICV, age and IQ. Ratio ROI mean value/(ICV * age * IQ estimate), df degree of freedom, p.adj (FDR) adjusted p-value, with false discovery rate corrected. BD Bipolar Disorder (n = 16), MDD Major Depressive Disorder (n = 19)