1 year follow-up | 5 years follow-up | |||||
---|---|---|---|---|---|---|
Absolute risk per 1000a | NNH | 95 % CIb | Absolute risk per 1000a | NNH | 95 % CIb | |
TCA | 1.6 | 1437 | 609 to 9786 | 8.1 | 217 | 143 to 363 |
SSRI | 1.4 | 2014 | 1014 to 7458 | 6.7 | 312 | 229 to 453 |
Other | 1.8 | 1125 | 472 to 6274 | 8.2 | 215 | 137 to 378 |
Combined | 5.5 | 217 | 82 to 705 | 9.5 | 166 | 74 to 551 |
Tricyclic and related antidepressants (TCA) | ||||||
Amitriptyline | 1.7 | 1332 | - | 6.8 | 306 | 161 to 819 |
Dosulepin | 1.5 | 1572 | - | 7.6 | 241 | 117 to 748 |
Lofepramine | 1.3 | 2565 | - | 10.8 | 138 | 64 to 392 |
Trazodone | 2.6 | 602 | - | 18.8 | 65 | 34 to 140 |
Selective serotonin reuptake inhibitors (SSRI) | ||||||
Citalopram | 1.8 | 1126 | 614 to 2745 | 7.1 | 278 | 193 to 434 |
Escitalopram | 1.2 | 3003 | - | 5.2 | 586 | - |
Fluoxetine | 1.3 | 2697 | - | 6.7 | 313 | 204 to 546 |
Paroxetine | 1.0 | 18372 | - | 7.1 | 280 | 129 to 1072 |
Sertraline | 0.7 | −4684 | - | 5.5 | 508 | - |
Other antidepressants | ||||||
Mirtazapine | 1.2 | 2962 | - | 6.0 | 396 | - |
Venlafaxine | 2.2 | 749 | 296 to 3731 | 9.9 | 156 | 93 to 294 |
All others | 1.3 | 2383 | - | 5.8 | 426 | - |
Combined | 5.5 | 216 | 82 to 700 | 9.4 | 168 | 74 to 569 |