TY - JOUR AU - Oedegaard, Ketil J. AU - Alda, Martin AU - Anand, Anit AU - Andreassen, Ole A. AU - Balaraman, Yokesh AU - Berrettini, Wade H. AU - Bhattacharjee, Abesh AU - Brennand, Kristen J. AU - Burdick, Katherine E. AU - Calabrese, Joseph R. AU - Calkin, Cynthia V. AU - Claasen, Ana AU - Coryell, William H. AU - Craig, David AU - DeModena, Anna AU - Frye, Mark AU - Gage, Fred H. AU - Gao, Keming AU - Garnham, Julie AU - Gershon, Elliot AU - Jakobsen, Petter AU - Leckband, Susan G. AU - McCarthy, Michael J. AU - McInnis, Melvin G. AU - Maihofer, Adam X. AU - Mertens, Jerome AU - Morken, Gunnar AU - Nievergelt, Caroline M. AU - Nurnberger, John AU - Pham, Son AU - Schoeyen, Helle AU - Shekhtman, Tatyana AU - Shilling, Paul D. AU - Szelinger, Szabolcs AU - Tarwater, Bruce AU - Yao, Jun AU - Zandi, Peter P. AU - Kelsoe, John R. PY - 2016 DA - 2016/05/05 TI - The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample JO - BMC Psychiatry SP - 129 VL - 16 IS - 1 AB - Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization and prophylaxis using mood-stabilizing medications to reduce both manic and depressive symptoms. Lithium remains the gold standard of treatment with the strongest data for both efficacy and suicide prevention. However, many patients do not respond to this medication, and clinically there is a great need for tools to aid the clinician in selecting the correct treatment. Large genome wide association studies (GWAS) investigating retrospectively the effect of lithium response are in the pipeline; however, few large prospective studies on genetic predictors to of lithium response have yet been conducted. The purpose of this project is to identify genes that are associated with lithium response in a large prospective cohort of bipolar patients and to better understand the mechanism of action of lithium and the variation in the genome that influences clinical response. SN - 1471-244X UR - https://doi.org/10.1186/s12888-016-0732-x DO - 10.1186/s12888-016-0732-x ID - Oedegaard2016 ER -