Fig. 1

iPSC-derived neurons as a cellular model of bipolar disorder and lithium response. Fibroblasts are grown from skin biopsies taken from participating subjects. These cells are treated with a combination of four transcription factors that reprogram the cells to stem cells. These iPSCs are then treated with a series of growth factors to differentiate them into a variety of neuronal types. In this way, neurons from patients can be compared to controls or lithium responders to non-responders