TY - JOUR AU - Williams, Leanne M. AU - Goldstein-Piekarski, Andrea N. AU - Chowdhry, Nowreen AU - Grisanzio, Katherine A. AU - Haug, Nancy A. AU - Samara, Zoe AU - Etkin, Amit AU - O’Hara, Ruth AU - Schatzberg, Alan F. AU - Suppes, Trisha AU - Yesavage, Jerome PY - 2016 DA - 2016/03/15 TI - Developing a clinical translational neuroscience taxonomy for anxiety and mood disorder: protocol for the baseline-follow up Research domain criteria Anxiety and Depression (“RAD”) project JO - BMC Psychiatry SP - 68 VL - 16 IS - 1 AB - Understanding how brain circuit dysfunctions relate to specific symptoms offers promise for developing a brain-based taxonomy for classifying psychopathology, identifying targets for mechanistic studies and ultimately for guiding treatment choice. The goal of the Research Domain Criteria (RDoC) initiative of the National Institute of Mental Health is to accelerate the development of such neurobiological models of mental disorder independent of traditional diagnostic criteria. In our RDoC Anxiety and Depression (“RAD”) project we focus trans-diagnostically on the spectrum of depression and anxiety psychopathology. Our aims are a) to use brain imaging to define cohesive dimensions defined by dysfunction of circuits involved in reactivity to and regulation of negatively valenced emotional stimulation and in cognitive control, b) to assess the relationships between these dimension and specific symptoms, behavioral performance and the real world capacity to function socially and at work and c) to assess the stability of brain-symptom-behavior-function relationships over time. SN - 1471-244X UR - https://doi.org/10.1186/s12888-016-0771-3 DO - 10.1186/s12888-016-0771-3 ID - Williams2016 ER -