Negative symptom | Sub-optimally controlled symptom | |||||
---|---|---|---|---|---|---|
5 mg (n = 10) | 10 mg (n = 47) | 20 mg (n = 48) | 5 mg (n = 5) | 10 mg (n = 25) | 20 mg (n = 25) | |
PANSS, mean (SD) | ||||||
Total score | ||||||
Baseline | 78.8 (9.9) | 79.7 (10.3) | 80.5 (7.4) | 87.2 (10.4) | 88.4 (12.2) | 91.0 (13.6) |
Change | −7.7 (5.7) | −11.0 (12.5) | −10.3 (15.9) | −9.4 (12.7) | −11.0 (14.0) | −7.5 (14.6) |
Negative symptom factor score | ||||||
Baseline | 25.9 (4.5) | 26.7 (4.7) | 26.8 (4.4) | 22.2 (6.2) | 22.6 (5.7) | 24.2 (6.4) |
Change | −4.8 (4.1) | −4.9 (4.7) | −4.9 (6.0) | −1.6 (3.7) | −3.7 (4.9) | −2.5 (4.8) |
Positive symptom factor score | ||||||
Baseline | 16.9 (3.3) | 17.3 (3.5) | 18.0 (3.2) | 26.2 (6.0) | 26.4 (3.8) | 26.5 (5.1) |
Change | −0.9 (0.9) | −1.7 (2.8) | −1.4 (3.8) | −4.2 (5.0) | −3.9 (4.5) | −2.1 (5.9) |
Disorganized thought/cognition factor score | ||||||
Baseline | 19.3 (2.5) | 19.3 (4.3) | 19.2 (3.0) | 18.2 (2.9) | 19.2 (3.7) | 20.8 (4.8) |
Change | −1.7 (1.9) | −2.5 (3.2) | −2.3 (3.6) | −1.8 (1.8) | −1.8 (3.0) | −1.4 (3.0) |
Uncontrolled hostility/excitement factor score | ||||||
Baseline | 6.5 (2.0) | 7.1 (2.4) | 7.0 (2.3) | 10.4 (4.4) | 9.5 (3.2) | 9.0 (2.5) |
Change | 0.5 (1.2) | −0.6 (1.6) | −0.5 (2.2) | −1.0 (1.4) | −0.9 (2.3) | −0.7 (2.0) |
Anxiety/depression factor score | ||||||
Baseline | 10.2 (2.4) | 9.3 (2.6) | 9.6 (2.8) | 10.2 (2.5) | 10.7 (2.7) | 10.5 (2.8) |
Change | −0.8 (1.2) | −1.3 (2.2) | −1.3 (2.3) | −0.8 (1.9) | −0.8 (2.1) | −0.9 (2.5) |
Responder in each symptoma, n (%) | 6 (60) | 27 (57) | 23 (49) | 2 (40) | 14 (56) | 7 (28) |
CGI, mean (SD) | ||||||
CGI-S of overall symptom | ||||||
Baseline | 3.6 (0.5) | 4.1 (0.6) | 4.2 (0.6) | 4.2 (0.4) | 4.2 (0.5) | 4.4 (0.6) |
Change | −0.1 (0.3) | −0.6 (0.9) | −0.6 (1.2) | −1.0 (1.0) | −0.8 (1.0) | −0.6 (1.0) |
CGI-S in each symptom | ||||||
Baseline | 4.4 (0.7) | 4.4 (0.6) | 4.5 (0.7) | 4.2 (0.4) | 4.3 (0.6) | 4.3 (0.6) |
Change | −0.8 (1.0) | −0.8 (1.0) | −0.9 (1.2) | −0.8 (1.1) | −0.9 (1.2) | −0.6 (1.2) |
CGI-I of overall symptomb, n (%) | 0 (0) | 8 (17) | 12 (26) | 1 (20) | 7 (28) | 3 (12) |
CGI-I in each symptomb, n (%) | 2 (20) | 9 (19) | 12 (26) | 1 (20) | 6 (24) | 4 (16) |
PSP total score, mean (SD) | ||||||
Baseline | 54.0 (16.2) | 50.0 (14.2) | 46.5 (16.0) | 45.4 (18.8) | 48.8 (15.6) | 46.1 (12.5) |
Change | 7.2 (7.3) | 7.3 (11.1) | 7.0 (13.8) | 10.6 (14.4) | 5.0 (7.4) | 6.8 (11.6) |