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Table 3 Sensitivity, specificity, positive and negative predictive values (PPV and NPV) and best cut-off point for scores of the 10-item and 5-item MADRS

From: Clinical utility of the Montgomery-Åsberg Depression Rating Scale for the detection of depression among bariatric surgery candidates

10-item MADRS
Cut-off 5/6 6/7 7/8 8/9 9/10 10/11 11/12 12/13 13/14 a 14/15 15/16
Sensitivity 0.92 0.92 0.92 0.90 0.87 0.85 0.85 0.85 0.85 0.77 0.69
Specificity 0.64 0.66 0.69 0.70 0.74 0.76 0.77 0.81 0.81 0.83 0.84
PPV 0.52 0.56 0.56 0.57 0.59 0.60 0.62 0.69 0.70 0.72 0.72
NPV 0.95 0.95 0.95 0.94 0.93 0.92 0.92 0.91 0.91 0.86 0.82
γ 0.56 0.58 0.61 0.62 0.62 0.61 0.62 0.66 0.66 0.60 0.53
5-item MADRS
Cut-off 5/6 6/7 7/8 8/9 9/10 10/11 a 11/12 12/13 13/14 14/15 15/16
Sensitivity 0.88 0.88 0.85 0.81 0.81 0.81 0.69 0.65 0.58 0.58 0.46
Specificity 0.75 0.76 0.81 0.85 0.86 0.87 0.88 0.90 0.90 0.90 0.93
PPV 0.57 0.56 0.61 0.70 0.71 0.75 0.74 0.78 0.76 0.76 0.81
NPV 0.71 0.94 0.94 0.91 0.91 0.90 0.85 0.82 0.79 0.79 0.72
γ 0.63 0.64 0.66 0.66 0.67 0.68 0.57 0.55 0.48 0.48 0.47
  1. γ Youden’s index = (sensitivity + specificity) - 1
  2. aMaximum trade-off between sensitivity and specificity
  3. Bold-data: MADRS' threshold scores