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Table 3 Analyses of the discrimination power of HCL-32 and its sub-domains in screening BDs

From: Investigation of the clinical utility of the hypomania checklist 32 (HCL-32) for the screening of bipolar disorders in the non-clinical adult population

  HCL-32 total Active/elated Irritable/risk-taking
BD1 vs Control
 AUC (95 % CI) 0.56 (0.51–0.61) 0.52 (0.47–0.57) 0.67 (0.62–0.72)
 optimal cut-off score >19 ≥12 >2
 PPV (%) 38.87 (28.89–49.60) 29.72 (23.42–36.65) 37.96 (31.07–45.24)
 NPV (%) 77.72 (72.22–81.52) 76.53 (70.50–81.86) 83.20 (77.77–87.76)
 sensitivity (95 % CI) 0.32 (0.24–0.42) 0.52 (0.42–0.62) 0.65 (0.55–0.74)
 specificity (95 % CI) 0.82 (0.77–0.86) 0.56 (0.50–0.62) 0.62 (0.56–0.67)
BD2 vs Control
 AUC 0.64 (0.60–0.69) 0.54 (0.49–0.59) 0.75 (0.70–0.79)
 optimal cut-off score >21 >11 >2
 PPV (%) 53.84 (43.54–71.23) 27.20 (22.06–32.84) 37.63 (30.82–44.81)
 NPV (%) 81.31 (76.95–85.17) 83.27 (76.12–88.99) 88.50 (83.60–92.36)
 sensitivity (95 % CI) 0.31 (0.22–0.40) 0.76 (0.66–0.83) 0.74 (0.64–0.82)
 specificity (95 % CI) 0.93 (0.90–0.96) 0.37 (0.32–0.43) 0.62 (0.56–0.67)
BDs vs Control
 AUC 0.60 (0.56–0.65) 0.51 (0.47–0.56) 0.71 (0.67–0.75)
 optimal cut-off score >19 >10 >2
 PPV (%) 58.44 (49.66–66.83) 43.31 (38.28–48.46) 56.07 (49.94–62.07)
 NPV (%) 64.57 (59.65–69.28) 63.82 (55.64–71.45) 73.99 (68.24–79.19)
 sensitivity (95 % CI) 0.36 (0.30–0.43) 0.75 (0.68–0.80) 0.69 (0.62–0.75)
 specificity (95 % CI) 0.82 (0.77–0.86) 0.31 (0.26–0.37) 0.62 (0.56–0.67)
  1. Cut-off score with the highest Youden’s Index value
  2. AUC the area under the curve of the receiver operating characteristic (ROC) curve, HCL-32 hypomania checklist 32, BD1 bipolar I disorder, BD2 bipolar II disorder, BDs bipolar disorders, PPV positive predictive value, NPV negative predictive value