Outcome measure | Study | Age (mean ± SD) | Sample (N) | Aims | Key measures | Key findings |
---|---|---|---|---|---|---|
Social and participation | [140]* | MHP: 28.74 ± 10.38 | MHP (38M; 28F) | Identify changes in the rates of obesity in never-treated patients with mood disorder over 4 years of follow-up. | Metabolic: BMI | MHP: ↑ BMI ~ ↑ social and economic participation |
(40 MDD, 26 BPD) | Functional: GAF | |||||
Physical health | [198] | FH+: 18.9 ± 1.0 | FH+ (32M, 53F) | Determine whether young people with a family history of depression have altered metabolic markers. | Metabolic/Functional: glucose, lipids and high-sensitivity CRP. BP, arterial stiffness and waking cortisol concentration. | FH+: ↑ peripheral and central BP, arterial stiffness and ↓ insulin sensitivity |
HC: 19.1 ± 0.1 | HC (27M; 42F) | |||||
Suicide and self-harm | [138] | SUC: 15.93 ± 1.48 | SUC (15M; 32F) | Examine the relationship between serum cholesterol levels and suicidal behaviours | Metabolic: blood serum samples | SUC: ↑ cholesterol ~ current suicide behaviour (within the SUC group, ↑ serum cholesterol ~ ↓ severity of SUC, but not ~ symptom severity) |
PC: 16.22 ± 1.95 | PC (58M; 47F) | Functional: SPI | ||||
 |  | PD: 25.3 ± 3.3 | PD (37M; 35F) | Elucidate the relationships between alexithymia, suicide ideation and serum lipid levels. | Metabolic: BMI, blood serum samples | PD: ↓ HDL-C and ↑ VLDL-C ~ higher suicide ideation |
Functional: SSI | ||||||
 | [137] | SA: 15.44 ± 1.99 | SA (17M; 49F) | Explore the associations between cholesterol and suicidal behaviour | Metabolic: blood serum samples | SA: ↓ cholesterol levels ~ attempted suicide history |
PC: 15.19 ± 1.68 | PC (15M; 39F) | Functional: hospital records | ||||
 | [199] | SA: 16.8 SEM = .74 | SA (3M; 6F) | Investigate platelet PBR density in suicidal teens | Metabolic: blood serum samples | SA: ↓ platelet PBR density |
PC: 16.5 SEM = .5 | PC (7M; 3F) | Functional: hospital records, SPI, SRS | ||||
 | [155] | SA: 15.87 ± 1.56 | SA(10M; 25F) | Evaluate the relationship between plasma serotonin levels and psychometric measures in suicidal adolescents | Metabolic: blood serum samples | SA: ↓ plasma 5-HT level ~ ↑ suicidality. (5-HT did not discriminate between the psychiatric diagnostic categories) |
PC: 16.29 1.81 | PC (19M; 11F) | Functional: hospital records, SPI | ||||
ER: 16.91 2.47 | ER (13M; 38F) | |||||
HC: 15.26 1.41 | HC (45M; 50F) | |||||
Alcohol and substance use | [200] | BPD-O: 12.9 ± 3.1 | BPD-O (77M; 68F) | Investigate obesity in paediatric bipolar patients and notable correlates | Metabolic: BMI | BPD: SUD ~ 2.8 fold increased prevalence of BPD-OB. |
BPD-NO: 13.3 ± 3.0 | BPD-NO (108M; 95F) | Functional: K-SADS-P | ||||
Clinical syndrome | [162] | MDD: 24.1 ± 3.2 | MDD (45M; 44F) | Examine the association between MDD in childhood and BMI in adulthood | Metabolic: BMI | MDD: ↑ BMI at FUP (in adulthood) |
HC: 22.2 ± 2.9 | HC (43M; 45F) | Clinical: KSADS, | ||||
 | [140]* | MHP: 28.74 ± 10.38 | MHP (38M; 28F) | Identify changes in the rates of obesity in never-treated patients with mood disorder over 4 years of follow-up. | Metabolic: BMI | MHP: clinical improvement ~ ↑ BMI |
(40 MDD, 26 BPD) | Clinical: HAMD |