Table 3 Mean changes in PETiT total and domain scores by prior medication in patients switched to long-term lurasidone therapy
| Â | Quetiapine | Olanzapine | Risperidone | Aripiprazole | Ziprasidone | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Core Study BL | Extension Study BL | Extension Study EP | Core Study BL | Extension Study BL | Extension Study EP | Core Study BL | Extension Study BL | Extension Study EP | Core Study BL | Extension Study BL | Extension Study EP | Core Study BL | Extension Study BL | Extension Study EP | ||
PETiT Total Score | N | 33a | 32b | 23c | 12a | 12b | 8c | 25a | 25b | 13c | 28a | 28b | 22c | 19a | 19b | 13c |
Mean Score (SD) | 30.1 (8.0) | 35.8 (9.6) | 34.0 (6.6) | 40.3 (11.8) | 43.1 (11.1) | 41.4 (12.1) | 36.4 (9.9) | 40.9 (8.5) | 39.4 (11.9) | 35.5 (7.6) | 40.1 (8.1) | 41 (7.7) | 35.5 (8.2) | 40.9 (7.4) | 39.5 (8.6) | |
Change from Core BL (SD) | -- | 5.3 (9.1) | 3.0 (6.0) | -- | 1.6 (5.6) | 3.1 (7.6) | -- | 5 (7.5) | 8.4 (9.6) | -- | 4.4 (6.9) | 5.5 (6.1) | -- | 5.4 (7.4) | 5.3 (7.2) | |
p-value | -- | 0.004 | 0.026 | -- | 0.082 | NEd | -- | 0.024 | 0.126 | -- | 0.021 | 0.002 | -- | 0.005 | 0.233 | |
Adherence-related Attitude Domain Score | Mean Score (SD) | 8.0 (2.2) | 9.2 (2.3) | 8.7 (2.0) | 9.2 (2.4) | 10.2 (1.7) | 9.4 (1.7) | 8.8 (2.1) | 10.1 (1.7) | 10.1 (2.2) | 8.3 (2.1) | 10.1 (1.7) | 10.2 (1.4) | 8.6 (2.0) | 9.9 (1.9) | 9.8 (1.9) |
Change from Core BL (SD) | -- | 1.3 (2.7) | 0.9 (2.5) | -- | 0.9 (2.1) | 0.6 (1.8) | -- | 1.3 (2.0) | 1.8 (2.5) | -- | 1.7 (2.1) | 1.8 (2.5) | -- | 1.3 (1.9) | 1.2 (2.5) | |
p-value | -- | 0.004 | 0.039 | -- | 0.226 | NEd | -- | 0.002 | 0.138 | -- | 0.001 | <0.001 | -- | 0.059 | 0.119 | |
Psychosocial Functioning Domain Score | Mean Score (SD) | 22.1 (7.0) | 26.6 (8.5) | 25.3 (6.1) | 31.1 (10) | 32.8 (9.6) | 32 (10.5) | 27.6 (8.7) | 30.8 (7.6) | 29.4 (10.3) | 27.3 (6.6) | 30.0 (7.3) | 30.8 (7.3) | 26.9 (7.2) | 31.1 (6.4) | 29.7 (7.6) |
Change from Core BL (SD) | -- | 3.9 (7.5) | 2.1 (4.4) | -- | 0.7 (4.3) | 2.5 (6.9) | -- | 3.8 (6.6) | 6.5 (8.0) | -- | 2.7 (5.8) | 3.7 (5.4) | -- | 4.1 (6.2) | 4.2 (5.3) | |
p-value | -- | 0.011 | 0.083 | -- | 0.200 | NEd | -- | 0.058 | 0.131 | -- | 0.081 | 0.013 | -- | 0.003 | 0.228 | |