Table 6 Mean changes in SF-12 PCS and MCS scores by prior medication in patients switched to long-term lurasidone therapy
| Â | Quetiapine | Olanzapine | Risperidone | Aripiprazole | Ziprasidone | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Core Study BL | Extension Study BL | Extension Study EP | Core Study BL | Extension Study BL | Extension Study EP | Core Study BL | Extension Study BL | Extension Study EP | Core Study BL | Extension Study BL | Extension Study EP | Core Study BL | Extension Study BL | Extension Study EP | ||
Physical Component Summary Score | N | 30a | 30b | 25c | 13a | 13b | 7δ | 27a | 27b | 14c | 31a | 31b | 20c | 17a | 17b | 14c |
Mean Score (SD) | 45.1 (11.5) | 42.9 (10.1) | 44.4 (9.8) | 50.3 (11.1) | 49.5 (10.2) | 49.3 (7.7) | 46.6 (9.4) | 49.7 (8.6) | 49.5 (6.5) | 46.2 (11.1) | 45.5 (11.0) | 51.1 (9.1) | 47.7 (10.5) | 45.7 (10.6) | 48.3 (9.7) | |
Change from Core BL (SD) | -- | −1.0 (9.5) | 0.9 (7.4) | -- | −0.2 (5.0) | 1.2 (10.1) | -- | 1.9 (9.5) | 2.0 (7.6) | -- | −0.9 (7.8) | 4.4 (7.7) | -- | −1.8 (6.3) | 2.5 (10.0) | |
p-value | -- | 0.555 | 0.524 | -- | 0.239 | NEd | -- | 0.302 | 0.055 | -- | 0.712 | 0.047 | -- | 0.166 | 0.497 | |
Mental Component Summary Score | N | 30 | 30 | 25 | 13 | 13 | 7 | 27 | 27 | 14 | 31 | 31 | 20 | 17 | 17 | 14 |
Mean Score (SD) | 38.9 (11.1) | 43.0 (12.3) | 42.7 (9.3) | 45.0 (12.1) | 52.0 (11.7) | 47.9 (10.9) | 42.0 (12.1) | 46.3 (11.0) | 50.2 (9.9) | 42.2 (8.1) | 46.1 (9.2) | 47.8 (9.3) | 40.7 (8.8) | 47.6 (9.6) | 47.4 (8.9) | |
Change from Core BL (SD) | -- | 4.8 (14.1) | 5.3 (10.9) | -- | 7.8 (9.1) | 3.0 (5.3) | -- | 4.7 (12.1) | 10.2 (14.4) | -- | 3.7 (8.4) | 6.0 (9.3) | -- | 7.7 (10.5) | 5.8 (9.5) | |
p-value | -- | 0.103 | 0.030 | -- | 0.224 | NEd | -- | 0.057 | <0.001 | -- | 0.039 | <0.001 | -- | 0.039 | 0.035 | |