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Table 5 Relative risk ratio (RRR) from multinomial logistic regression of having a continued prescription of benzodiazepines according to different factors

From: Benzodiazepine prescription for patients in treatment for drug use disorders: a nationwide cohort study in Denmark, 2000–2010

  Prescription of benzodiazepines 1 year after admission in moderate-high doses <584 DDDa Prescription of benzodiazepines 1 year after admission in very high doses ≥584 DDDa
  Unadjusted RRR Adjustedb RRR
(95 % CI)
p value Unadjusted RRR Adjustedb RRR
(95 % CI)
p value
Female 1.1 1.0 (0.9-1.2) 0.310 1.2 1.0 (0.9-1.2) 0.639
Age group at admission date
 18 – 27 years 1.0 (referent) 1.0 (referent)   1.0 (referent) 1.0 (referent)  
 28 – 37 years 1.8 1.7 (1.4-1.9) <0.001 3.8 2.8 (2.3-3.5) <0.001
 38 – 47 years 2.4 2.1 (1.8-2.4) <0.001 7.6 4.9 (4.0-6.1) <0.001
 48 – 67 years 3.7 3.3 (2.7-3.9) <0.001 13.3 7.8 (6.2-9.9) <0.001
Primary drug use at admission
 Cannabis 1.0 (referent) 1.0 (referent)   1.0 (referent) 1.0 (referent)  
 Methadone or buprenorphine 2.4 1.8 (1.5-2.2) <0.001 15.2 8.3 (6.2-11.1) <0.001
 Heroin 1.5 1.3 (1.1-1.6) 0.001 5.1 3.6 (2.7-4.8) <0.001
 Other opioids 2.0 1.5 (1.1-2.1) 0.005 9.1 5.2 (3.6-7.7) <0.001
 Benzodiazepines 2.5 2.1 (1.5-2.8) <0.001 9.4 6.9 (4.5-10.6) <0.001
 Central stimulating drugsc 0.9 0.9 (0.7-1.1) 0.431 1.1 1.1 (0.7-1.7) 0.633
 Other illicit drugs/unknown 1.7 1.4 (1.2-1.6) <0.001 7.6 4.6 (3.5-6.0) <0.001
Psychiatric treatment received in 1 year prior to admissiond 1.0 1.2 (1.0-1.3) 0.006 0.6 0.6 (0.5-0.7) <0.001
  1. Group of previous users without prescription of benzodiazepines, n = 2464; group of previous users with prescription of benzodiazepines in moderate-high doses, n = 4113; group of previous users with prescription of benzodiazepines in very high doses, n = 2026.
  2. Abbreviations: DDD, Defined Daily Dose; CI, confidence interval.
  3. aIntake of 1 DDD daily of benzodiazepines in a 1 year period results in a total intake of 365 DDD.
  4. bAdjusted for gender, age group at admission date, primary drug use at admission, and psychiatric treatment received in 1 year prior to admission.
  5. cAmphetamine, cocaine, and MDMA.
  6. dInformation obtained from the Danish Psychiatric Central Research Register.