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Table 6 Relative risk ratio (RRR) from multinomial logistic regression of having a new prescription of benzodiazepines according to different factors

From: Benzodiazepine prescription for patients in treatment for drug use disorders: a nationwide cohort study in Denmark, 2000–2010

 

Prescription of benzodiazepines 1 year after admission in moderate-high doses <584 DDDa

Prescription of benzodiazepines 1 year after admission in very high doses ≥584 DDDa

 

Unadjusted RRR

Adjustedb RRR

(95 % CI)

p value

Unadjusted RRR

Adjustedb RRR

(95 % CI)

p value

Female

1.2

1.2 (1.1-1.3)

<0.001

0.8

0.8 (0.5-1.2)

0.818

Age group at admission date

 18 – 27 years

1.0 (referent)

1.0 (referent)

 

1.0 (referent)

1.0 (referent)

 

 28 – 37 years

1.7

1.4 (1.2-1.5)

<0.001

4.1

1.9 (1.3-2.9)

0.003

 38 – 47 years

1.9

1.3 (1.2-1.5)

<0.001

3.8

1.2 (0.7-2.0)

0.488

 48 – 67 years

1.9

1.3 (1.1-1.5)

0.006

4.0

1.1 (0.6-2.2)

0.710

Primary drug use at admission

 Cannabis

1.0 (referent)

1.0 (referent)

 

1.0 (referent)

1.0 (referent)

 

 Methadone or buprenorphine

4.2

3.8 (3.2-4.4)

<0.001

52.9

45.7 (20.9-99.9)

<0.001

 Heroin

2.7

2.5 (2.2-2.9)

<0.001

20.3

17.1 (8.0-36.5)

<0.001

 Other opioids

2.8

2.4 (1.7-3.3)

<0.001

22.5

20.3 (6.5-63.7)

<0.001

 Benzodiazepines

4.2

3.8 (2.7-5.4)

<0.001

14.2

15.1 (3.2-71.7)

0.001

 Central stimulating drugsc

1.1

1.0 (0.9-1.2)

0.572

1.9

1.9 (0.7-5.6)

0.224

 Other illicit drugs/unknown

1.5

1.4 (1.3-1.7)

<0.001

5.3

5.2 (2.3-11.4)

<0.001

Psychiatric treatment received in 1 year prior to admissiond

1.4

1.5 (1.4-1.7)

<0.001

0.5

0.7 (0.4-1.3)

0.320

  1. Group without prescription of benzodiazepines, n = 22034; group of new users with prescription of benzodiazepines in moderate-high doses, n = 2415; group of new users with prescription of benzodiazepines in very high doses, n = 151
  2. Abbreviations: DDD, Defined Daily Dose; CI, confidence interval
  3. aIntake of 1 DDD daily of benzodiazepines in a 1 year period results in a total intake of 365 DDD
  4. bAdjusted for gender, age group at admission date, primary drug use at admission, and psychiatric treatment received in 1 year prior to admission
  5. cAmphetamine, cocaine, and MDMA
  6. dInformation obtained from the Danish Psychiatric Central Research Register