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Table 6 Relative risk ratio (RRR) from multinomial logistic regression of having a new prescription of benzodiazepines according to different factors

From: Benzodiazepine prescription for patients in treatment for drug use disorders: a nationwide cohort study in Denmark, 2000–2010

  Prescription of benzodiazepines 1 year after admission in moderate-high doses <584 DDDa Prescription of benzodiazepines 1 year after admission in very high doses ≥584 DDDa
  Unadjusted RRR Adjustedb RRR
(95 % CI)
p value Unadjusted RRR Adjustedb RRR
(95 % CI)
p value
Female 1.2 1.2 (1.1-1.3) <0.001 0.8 0.8 (0.5-1.2) 0.818
Age group at admission date
 18 – 27 years 1.0 (referent) 1.0 (referent)   1.0 (referent) 1.0 (referent)  
 28 – 37 years 1.7 1.4 (1.2-1.5) <0.001 4.1 1.9 (1.3-2.9) 0.003
 38 – 47 years 1.9 1.3 (1.2-1.5) <0.001 3.8 1.2 (0.7-2.0) 0.488
 48 – 67 years 1.9 1.3 (1.1-1.5) 0.006 4.0 1.1 (0.6-2.2) 0.710
Primary drug use at admission
 Cannabis 1.0 (referent) 1.0 (referent)   1.0 (referent) 1.0 (referent)  
 Methadone or buprenorphine 4.2 3.8 (3.2-4.4) <0.001 52.9 45.7 (20.9-99.9) <0.001
 Heroin 2.7 2.5 (2.2-2.9) <0.001 20.3 17.1 (8.0-36.5) <0.001
 Other opioids 2.8 2.4 (1.7-3.3) <0.001 22.5 20.3 (6.5-63.7) <0.001
 Benzodiazepines 4.2 3.8 (2.7-5.4) <0.001 14.2 15.1 (3.2-71.7) 0.001
 Central stimulating drugsc 1.1 1.0 (0.9-1.2) 0.572 1.9 1.9 (0.7-5.6) 0.224
 Other illicit drugs/unknown 1.5 1.4 (1.3-1.7) <0.001 5.3 5.2 (2.3-11.4) <0.001
Psychiatric treatment received in 1 year prior to admissiond 1.4 1.5 (1.4-1.7) <0.001 0.5 0.7 (0.4-1.3) 0.320
  1. Group without prescription of benzodiazepines, n = 22034; group of new users with prescription of benzodiazepines in moderate-high doses, n = 2415; group of new users with prescription of benzodiazepines in very high doses, n = 151
  2. Abbreviations: DDD, Defined Daily Dose; CI, confidence interval
  3. aIntake of 1 DDD daily of benzodiazepines in a 1 year period results in a total intake of 365 DDD
  4. bAdjusted for gender, age group at admission date, primary drug use at admission, and psychiatric treatment received in 1 year prior to admission
  5. cAmphetamine, cocaine, and MDMA
  6. dInformation obtained from the Danish Psychiatric Central Research Register