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Table 3 Affected areas and sides of studies included in the meta-analysis

From: Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder

Citation Area Effect
Aybek, et al. [52] Midbrain including periaqueductal grey area (bi), premotor and supplementary areas (bi), dorsolateral prefrontal cortex (l), cingulate cortex (l) superior frontal gyrus (l) increased BOLD response
Aybek, et al. [47] Supplementary motor area (r), postcentral gyrus BA1 (r), postcentral gyrus BA4/3b (r), superior temporal gyrus (r), angular gyrus at temporoparietal junction (r), supramarginal gyrus at temporoparietal junction (r) increased BOLD response
lingual gyrus (l), parahippocampal gyrus (l), hippocampus (l) decreased BOLD response
Czarnecki, et al. [60] cerebellar hemispheres (bi), superior orbital gyrus (l), inferior frontal gyrus (l), insula (l), precentral and postcentral gyri (l), supplementary motor area (r), cerebellar hemisphere and vermis (ipsi), supplementary motor area (r) increased rCBF
medial prefrontal cortex (bi), anterior cingulate cortex (l), cerebellum (l), lingual gyrus (l) reduced rCBF
de Lange, et al. [16] dorsal intraparietal sulcus (r), dorsal precentral sulcus (bi), posterior end of the Sylvian fissure increased BOLD response to task complexity
superior temporal cortex (l), parietal operculum, prefrontal cortex, superior temporal cortex (r), posterior end of the Sylvian fissure increased BOLD response for the affected hand
de Lange, et al. [64] dorsal parietal and premotor cortex increased BOLD response to task complexity
frontal cortex, gyrus rectus, superior temporal cortex increased BOLD response for the affected hand
Elzinga, et al. [46] anterior prefrontal cortex (l), dorsolateral prefrontal cortex (l), parietal lobe (l) increased BOLD response
Spence, et al. [20] dorsolateral prefrontal cortex reduced rCBF
Stone, et al. [74] basal ganglia, insula, lingual gyri, interior frontal cortex, right middle frontal gyrus (r), orbitofrontal cortex increased BOLD response
van Beilen, et al. [50] cingulate cortex (l), vental premotor cortex (ipsi), supramarginal cortex (ipsi), superior temporal cortex (contra + ipsi), anterior cingulate cortex (contra + ipsi), triangular cortex inferior frontal (contra) increased BOLD response
supramarginal gyrus (r), dlPFC (r), frontal pole (ipsi), ventral lateral prefrontal (ipsi), precuneus (contra), cerebellum (ipsi) decreased BOLD response
Voon, et al. [43] anterior cingulate gyrus (l), primary motor cortex (l), somatosensory cortex (l), secondary visual cortex (r), ventral premotor cortex (ipsi), supramarginal cortex (bi), anterior cingulate cortex (contra), triangular cortex (contra) increased BOLD response
primary motor cortex (r), somatosensory cortex (r), dorsolateral prefrontal cortex (r), medial frontal pole (r), insular cortex (l), cerebellum (l), frontal pole (ipsi), ventral lateral prefrontal (ipsi), precuneus (contra), cerebellum (ipsi), supplementary motor cortex (contra), frontal pole (contra), ventrolateral prefrontal cortex (ipsi), orbitofrontal cortex (ipsi), supramarginal cortex (contra), precuneus (contra), superior parietal cortex (contra), frontal eye fields (contra) decreased BOLD response
Voon, et al. [27] amygdala increased BOLD response
amygdala to supplementary motor area more connectivitya
Vuilleumier, et al. [22] Thalamus, caudate, putamen decreased rCBF before treatment
  1. l left, r right, bi both sides, dlPFC dorsolateral prefrontal cortex, rCBF relative cerebral blood flow, BOLD blood oxygen level dependent. aconnectivity was measured as interregional correlation between conversion tremor and voluntary tremor within the same patients