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Table 4 Comparison of previous reports

From: Prevalence of elevated serum anti-N-methyl-D-aspartate receptor antibody titers in patients presenting exclusively with psychiatric symptoms: a comparative follow-up study

  n M/F Diagnosis Positive Prevalence Antibody measure method
Rhoads et al. 2011 [4] 7 3/4 Schizophrenia 0 0.0 % Cell-based assay NR1
Zandi et al. 2011 [7] 46 ns Early-stage psychiatric disorder 4 6.5 % Cell-based assay NR1/NR2B
   Schizophrenia 63 %    
   Atypical psychosis 15 %    
   Mood disorder 4 %    
   Bipolar disorder 4 %   
   Major depression 2 %   
   Paranoia 2 %   
Haussleiter et al. 2012 [5] 50 17/33 Psychiatric disorder 0 0.0 % Cell-based assay NR1/NR2B, NR1/NR1
Masdeu et al. 2012 [6] 80   Schizophrenia 0 0.0 % Cell-based assay NR1
Tsutsui et al. 2012 [8] 51 ns Schizophrenia 4 7.8 % Cell-based assay NR1/NR2B
5 ns Narcolepsy with psychiatric symptom 3 60.0 %
Steiner et al. 2013 [9] 121 77/44 Schizophrenia 12 9.9 % Cell-based assay NR1/NR2B
70 26/44 Major depression 2 2.8 %  
38 14/24 Borderline personality disorder 0 0.0 %
Hammer et al. 2014 [10] 1272 780/492 Healthy control 137 10.8 % Cell-based assay NR1/NR2B
1081 723/358 Schizophrenia 93 8.6 %  
148 70/78 Affective disorder 24 16.2 %
Steiner et al. 2014 [11] 357 ns Healthy control 25 7.0 % Indirect immunofluorescence BIOCHIP assay (commercial)
184 ns Schizophrenia 18 9.8 %
99 ns Major depression 5 5.1 %
42 ns Borderline personality disorder 1 2.4 %
Our report 2015 59 23/36 Total 6 10.2 % Cell-based assay NR1/NR2B
44 15/29 Schizophrenia 4 9.1 %  
1 1/0 Major depression 1 100.0 %  
4 1/3 Undetermined 1 25.0 %  
1 1/0 Nonherpetic limbic encephalitis 0 0.0 %  
1 0/1 Atypical psychosis 0 0.0 %
4 1/3 Acute transient psychosis 0 0.0 %
1 1/0 Bipolar disorder 0 0.0 %
2 1/1 Organic psychosis 0 0.0 %
1 1/0 Mental retardation 0 0.0 %