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Table 4 Comparison of previous reports

From: Prevalence of elevated serum anti-N-methyl-D-aspartate receptor antibody titers in patients presenting exclusively with psychiatric symptoms: a comparative follow-up study

 

n

M/F

Diagnosis

Positive

Prevalence

Antibody measure method

Rhoads et al. 2011 [4]

7

3/4

Schizophrenia

0

0.0 %

Cell-based assay NR1

Zandi et al. 2011 [7]

46

ns

Early-stage psychiatric disorder

4

6.5 %

Cell-based assay NR1/NR2B

  

Schizophrenia 63 %

   
  

Atypical psychosis 15 %

   
  

Mood disorder 4 %

   
  

Bipolar disorder 4 %

  
  

Major depression 2 %

  
  

Paranoia 2 %

  

Haussleiter et al. 2012 [5]

50

17/33

Psychiatric disorder

0

0.0 %

Cell-based assay NR1/NR2B, NR1/NR1

Masdeu et al. 2012 [6]

80

 

Schizophrenia

0

0.0 %

Cell-based assay NR1

Tsutsui et al. 2012 [8]

51

ns

Schizophrenia

4

7.8 %

Cell-based assay NR1/NR2B

5

ns

Narcolepsy with psychiatric symptom

3

60.0 %

Steiner et al. 2013 [9]

121

77/44

Schizophrenia

12

9.9 %

Cell-based assay NR1/NR2B

70

26/44

Major depression

2

2.8 %

 

38

14/24

Borderline personality disorder

0

0.0 %

Hammer et al. 2014 [10]

1272

780/492

Healthy control

137

10.8 %

Cell-based assay NR1/NR2B

1081

723/358

Schizophrenia

93

8.6 %

 

148

70/78

Affective disorder

24

16.2 %

Steiner et al. 2014 [11]

357

ns

Healthy control

25

7.0 %

Indirect immunofluorescence BIOCHIP assay (commercial)

184

ns

Schizophrenia

18

9.8 %

99

ns

Major depression

5

5.1 %

42

ns

Borderline personality disorder

1

2.4 %

Our report 2015

59

23/36

Total

6

10.2 %

Cell-based assay NR1/NR2B

44

15/29

Schizophrenia

4

9.1 %

 

1

1/0

Major depression

1

100.0 %

 

4

1/3

Undetermined

1

25.0 %

 

1

1/0

Nonherpetic limbic encephalitis

0

0.0 %

 

1

0/1

Atypical psychosis

0

0.0 %

4

1/3

Acute transient psychosis

0

0.0 %

1

1/0

Bipolar disorder

0

0.0 %

2

1/1

Organic psychosis

0

0.0 %

1

1/0

Mental retardation

0

0.0 %