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Table 1 The inclusion and exclusion criteria for MDD patients and healthy controls, respectively

From: The establishment of the objective diagnostic markers and personalized medical intervention in patients with major depressive disorder: rationale and protocol

Study group Inclusion criteria Exclusion criteria
1200-MDD patients (1) age between 18 and 55 years at the time of enrollment;
(2) diagnosis of MDD based on the Chinese Version of MINI according to DSM-IV TR;
(3) first-episode or relapsed;
(4) having the ability of reading and writing to complete the questionnaire and psychological assessment;
(5) providing written confirmation of informed consent.
(1) lifetime or current diagnosis of other psychotic disorder, alcohol/substances dependence or cognitive impairment;
(2) severe somatic diseases, such as severe cardio-cerebral vascular diseases, respiratory diseases, liver diseases, kidney diseases, or malignant tumors;
(3) not signed the informed consent;
(4) been engaging in other studies.
600-MDD patients subgroup Besides those same as 1200-MDD patients’, more inclusion criteria are as the follows:
(1) first-episode or relapsed more than1 time in the past 3 years and in acute episode period;
(2) total score of HRSD17 ≥ 14 when being screened;
(3) not taking anti-depressant regularly in the past 2 weeks or should change anti-depressant according to the psychiatrist’s advice.
Besides those same as 1200-MDD patients’, more exclusion criteria are as the follows:
(1) resistant depression (not improved after taking 2 kinds of anti-depressant with adequate dosage and duration;
(2) having history of epilepsy;
(3) taking MECT therapy in the past 3 months;
(4) pregnant or breast-feeding.
1200-Healthy controls (1) age between 18 and 55 years at the time of enrollment;
(2) providing written confirmation of informed consent prior to engaging the study.
(1) lifetime or current diagnosis of any mental diseases;
(2) severe somatic diseases, such as severe cardio-cerebral vascular diseases, respiratory diseases, liver diseases, kidney diseases, or malignant tumors;
(3) not signed the informed consent;
(4) been engaging other studies.
  1. Abbreviations: MDD major depressive disorder, MINI mini-international neuropsychiatric interview, DSM-IV TR diagnostic and statistical manual of mental disorders, fourth edition text revision, HRSD17 the 17-item Hamilton rating scale for depression, MECT modified electric convulsive therapy