Genomic ancestry and the social pathways leading to major depression in adulthood: the mediating effect of socioeconomic position and discrimination

Table 3 Multivariable regression models for major depression and African ancestry by tertiles of socioeconomic position (SEP)

	N	African ancestry median [IQR]	African ancestry	PR (95 % CI)^a	p-value^b
SEP
1 ^st tertile	756	0.09 [0.05–0.30]	0–5 %	1	0.293
			>5 %–30 %	0.98 (0.60–1.59)
			>30 %–90 %	0.74 (0.42–1.31)
2 ^nd tertile	767	0.07 [0.04–0.18]	0–5 %	1	0.997
			>5 %–30 %	1.02 (0.56–1.87)
			>30 %–90 %	0.99 (0.48–2.04)
3 ^rd tertile	724	0.05 [0.03–0.09]	0–5 %	1	0.009
			>5 %–30 %	2.16 (1.05–4.45)
			>30 %–90 %	2.74 (1.06–7.06)

PR prevalence ratio, CI confidence interval, IQR interquartile range
^aMultivariable models using major depression as the outcome and African ancestry as main exposure are adjusted for sex
^bTrend p-value for African ancestry in each tertile of SEP

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