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Table 4 Drug treatment of seizures and mental disorders in the 12 months prior to first documentation

From: Characterization, treatment patterns, and patient-related outcomes of patients with Fragile X syndrome in Germany: final results of the observational EXPLAIN-FXS study

Comorbidity category (n of afflicted patients)

Substance

Patient number

≤13 years (n = 40)

14-17 years (n = 11)

18+ years (n = 24)

Total (all patients, n = 75)

n (%)

n (%)

n (%)

n (%)

ADH (36)

Amphetamine

9 (37.5)

4 (57.1)

1 (20.0)

13 (17.1)

Atomoxetine, Desipramine, etc.

0

1 (14.3)

0

2 (2.6)

Methylphenidate

9 (37.5)

3 (42.9)

1 (20.0)

14 (18.4)

Risperidone, Quetiapine, etc.

3 (12.5)

1 (14.3)

0

6 (7.9)

Other

11 (45.8)

2 (28.6)

1 (20.0)

14 (18.4)

Anxiety (22)

Fluoxetine, Fluvoxamine, etc.

5 (41.7)

2 (66.7)

2 (28.6)

9 (11.8)

Amitriptyline, Imipramine, etc.

0

0

0

 

Diazepam, Lorazepam, etc.

0

0

0

 

Risperidone, Clozapine, etc.

0

0

2 (28.6)

2 (2.6)

Other

6 (50.0)

2 (66.7)

1 (14.3)

9 (11.8)

Conduct disorders (39)

Methylphenidate, Amphetamine, etc.

8 (36.4)

2 (33.3)

2 (18.2)

12 (15.8)

Pipamperone, Melperone, etc.

0

0

0

1 (1.3)

Risperidone, Clozapine, etc.

5 (22.7)

0

2 (18.2)

10 (13.2)

Other

14 (63.6)

4 (66.7)

4 (36.4)

23 (30.3)

Depression (7)

Fluvoxamine, Citalopram, etc.

2 (66.7)

1 (100.0)

1 (33.3)

4 (5.3)

Venlafaxine, Bupropion, etc.

0

1 (100.0)

0

 

Lithium

 

1 (100.0)

  

Other

1 (33.3)

0

0

1 (1.3)

Seizures (6)

Valproate

1 (20.0)

0

1 (100.0)

2 (2.6)

Other

3 (60.0)

0

1 (100.0)

6 (7.9)

  1. Values indicate patient numbers (n) and, in brackets, the percentage of afflicted patients in the respective age group