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Table 2 Score differences between pre-treatment and post-treatment ratings

From: Treatment of trauma-affected refugees with venlafaxine versus sertraline combined with psychotherapy - a randomised study

Rating Groups and differences Mean pre-treatment score (SE) Mean post-treatment score (SE) Difference (SE) P-value Effect size
Symptoms self-ratings
HTQ Sertraline 3.24 (0.04) 3.02 (0.06) 0.22 (0.06) <0.01** 0.54
Venlafaxine 3.18 (0.05) 3.05 (0.06) 0.13 (0.06) 0.02* 0.32
Difference 0.06 (0.06) −0.03 (0.09) 0.09 (0.08) 0.27 0.22
HSCL-25 Sertraline 3.03 (0. 05) 2.85 (0.07) 0.18 (0.07) <0.01** 0.39
Venlafaxine 3.04 (0.05) 2.94 (0.06) 0.10 (0.05) 0.05* 0.22
Difference −0.01 (0.07) −0.09 (0.09) 0.08 (0.09) 0.37 0.17
SCL-90 Sertraline 2.40 (0.08) 2.35 (0.10) 0.05 (0.10) 0.64 0.06
Venlafaxine 2.50 (0.08) 2.53 (0.09) −0.03 (0.07) 0.69 0.04
Difference −0.10 (0.10) −0.18 (0.13) 0.08 (0.12) 0.54 0.10
VAS Sertraline 6.38 (0.24) 6.17 (0.28) 0.21 (0.26) 0.43 0.26
Venlafaxine 6.61 (0.24) 6.68 (0.24) −0.07 (0.20) 0.72 0.03
Difference −0.23 (0.34) −0.51 (0.36) 0.28 (0.33) 0.40 0.12
Life quality/level of functioning self-ratings
WHO-5 Sertraline 12.73 (1.36) 22.21 (2.67) −9.48 (2.42) <0.01** 0.65
Venlafaxine 15.00 (1.64) 17.75 (2.24) −2.75 (2.16) 0.20 0.19
Difference −2.27 (2.13) 4.46 (3.49) 6.73 (3.24) 0.04* 0.47
SDS Sertraline 24.65 (0.53) 21.81 (0.88) 2.84 (0.85) <0.01** 0.48
Venlafaxine 22.71 (0.69) 23.20 (0.79) −0.49 (0.86) 0.57 0.08
Difference 1.93 (0.87)* −1.39 (1.17) 3.32 (1.21) <0.01** 0.56
SAS-SR Sertraline 2.93. (0.07) 2.68 (0.08) 0.25 (0.07) <0.01** 0.36
Venlafaxine 2.96 (0.07) 2.80 (0.0.08) 0.16 (0.08) 0.04* 0.23
Difference −0.03 (0.10) −0.12 (0.11) 0.09 (0.11) 0.39 0.13
CSS Sertraline 22.34 (0.89) 22.89 (0.80) −0.55 (0.79) 0.48 0.07
Venlafaxine 22.14 (0.76) 22.40 (0.79) −0.26 (0.73) 0.72 0.03
Difference 0.20 (1.17) 0.49 (1.13) 0.29 (1.07) 0.79 0.04
Observer ratings
HAM-D Sertraline 23.69 (0.55) 22.33 (0.85) 1.36 (0.79) 0.08 0.24
Venlafaxine 23.69 (0.62) 22.46 (0.89) 1.23 (0.82) 0.13 0.22
Difference 0.00 (0.83) −0.13 (1.23) 0.13 (1.14) 0.91 0.02
HAM-A Sertraline 26.74 (0.68) 26.41 (1.04) 0.33 (0.97) 0.73 0.05
Venlafaxine 27.14 (0.72) 26.05 (1.05) 1.09 (1.00) 0.28 0.16
Difference −0.40 (0.99) 0.36 (1.49) −0.76 (1.39) 0.58 0.11
GAF-S Sertraline 47.43 (0.57) 51.33 (0.93) −3.90 (0.79) <0.01** 0.68
Venlafaxine 48.14 (0.61) 51.82 (0.94) −3.68 (1.03) <0.01** 0.64
Difference −0.70 (0.83) −0.48 (1.32) 0.22 (1.29) 0.86 0.04
GAF-F Sertraline 48.37 (0.68) 50.28 (0.92) −1.91 (0.79) 0.02* 0.29
Venlafaxine 49.04 (0.68) 51.91 (0.96) −2.87 (0.89) <0.01** 0.43
Difference −0.67 (0.97) −1.63 (1.33) 0.96 (1.19) 0.42 0.06
  1. HAM = 0–4 (0 best score), GAF = 0–100 (100 best score), WHO-5 = 0–100 (100 best score), SDS = 0–30 (0 best score), SAS-SR = 1–5 (1 best score), CSS = 1–7 (7 best), HTQ, HSCL-25, SCL = 1–4 (1 best score), VAS = 0–10 (0 best score)
  2. WHO-5 WHO-Five Well-being Index, SDS Sheehan Disability scale, SAS-SR Social Adjustment Scale - Self Report, CSS Crisis Support Scale, HTQ Harvard Trauma Questionnaire, HSCL-25 Hopkins Symptom Checklist-25, SCL-90 Symptom Checklist-90, VAS Visual Analogue Scale (for pain), HAM-A Hamilton Anxiety scale and HAM-D Hamilton Depression scale, GAF Global Assessment of Functioning (S = symptom score and F = functioning score)
  3. Overview over pre-treatment and post-treatment rating scores for the intention-to-treat sample. In the right column the p-values refer to the significance of differences between pre- and post-treatment ratings in each group and the significance of group differences in the difference between pre- and post treatment ratings (corresponding to the interaction between intervention group and rating time). Based on the mixed model for the full sample group differences at the pre- and post-treatment assessments were estimated as simple main effects and so were the pre-post treatment differences for each intervention group. The group difference in pre-post treatment differences corresponds to the interaction coefficient in mixed model. SE = Robust standard error Effect size: The effect size calculated as the pre-post score difference/the baseline standard deviation
  4. * = statistically significant (p = 0.05 or below), ** = higly statistical significant (p = 0.01 or below)
  5. Bold = Improvement, Italic = Deterioration