Group | Baseline | 4 weeks | 12 weeks | 20 weeks | 26 weeks | 34 weeks | 52 weeks | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(mg/d) | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD |
4-week dose | 4.4 | 0.8 | 4.2 | 0.8 | 2.2a | 0.4 | 2.2 | 0.5 | 2.1 | 0.4 | 2.1 | 0.4 | 2.1 | 0.4 |
26-week dose | 4.2 | 0.5 | 4.2 | 0.6 | 4.2 | 0.5 | 4.2 | 0.5 | 3.8 | 0.9 | 2.1b | 0.3 | 2.0 | 0.3 |
Therapeutic dose | 4.3 | 0.6 | 4.3 | 0.6 | 4.2 | 0.7 | 4.3 | 0.6 | 4.2 | 0.6 | 4.3 | 0.6 | 4.2 | 0.6 |