Skip to main content

Table 4 Cox proportional hazards model with possible factors associated with detecting moderate to severe neutropenia and agranulocytosis

From: Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in Iceland

 

Hazard Ratio

Standard Error

Z-Score

95% CI

P-value

 A. Neutrophils 0 - 1900/mm3

 Patient on clozapine

1.33

0.33

1.14

0.81-2.18

0.25

 Sex (female)

1.82

0.40

2.76

1.19-2.80

0.01

 Average age at risk

0.97

0.01

−3.75

0.96-0.99

<0.001

 Measurements per year

1.14

0.02

6.32

1.09-1.18

<0.001

B. Neutrophils 0 – 1400/mm3 (equivalent to red result)

 Patient on clozapine

0.74

0.33

−0.68

0.31-1.76

0.50

 Sex (female)

2.00

0.67

2.08

1.04-3.88

0.04

 Average age at risk

0.98

0.01

−1.47

0.96-1.00

0.14

 Measurements per year

1.17

0.04

4.66

1.10-1.26

<0.001

C. Neutrophils 1000 - 1900/mm3

 Patient on clozapine

1.44

0.37

1.39

0.86-2.40

0.18

 Sex (female)

1.76

0.41

2.46

1.12-2.77

0.03

 Average age at risk

0.97

0.01

−3.85

0.95-0.98

<0.001

 Measurements per year

1.13

0.02

5.98

1.09-1.18

<0.001

D. Neutrophils 1500 – 1900/mm3 (equivalent to amber result)

 Patient on clozapine

1.86

0.58

1.99

1.00-3.43

0.05

 Sex (female)

1.70

0.49

1.85

0.97-3.00

0.09

 Average age at risk

0.96

0.01

−3.70

0.94-0.98

<0.001

 Measurements per year

1.12

0.03

4.62

1.06-1.17

<0.001

  1. A) n = 587, 89 cases. B) n = 587, 37 cases. C) n = 587, 80 cases. D) n = 587, 52 cases