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Table 4 Cox proportional hazards model with possible factors associated with detecting moderate to severe neutropenia and agranulocytosis

From: Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in Iceland

  Hazard Ratio Standard Error Z-Score 95% CI P-value
 A. Neutrophils 0 - 1900/mm3
 Patient on clozapine 1.33 0.33 1.14 0.81-2.18 0.25
 Sex (female) 1.82 0.40 2.76 1.19-2.80 0.01
 Average age at risk 0.97 0.01 −3.75 0.96-0.99 <0.001
 Measurements per year 1.14 0.02 6.32 1.09-1.18 <0.001
B. Neutrophils 0 – 1400/mm3 (equivalent to red result)
 Patient on clozapine 0.74 0.33 −0.68 0.31-1.76 0.50
 Sex (female) 2.00 0.67 2.08 1.04-3.88 0.04
 Average age at risk 0.98 0.01 −1.47 0.96-1.00 0.14
 Measurements per year 1.17 0.04 4.66 1.10-1.26 <0.001
C. Neutrophils 1000 - 1900/mm3
 Patient on clozapine 1.44 0.37 1.39 0.86-2.40 0.18
 Sex (female) 1.76 0.41 2.46 1.12-2.77 0.03
 Average age at risk 0.97 0.01 −3.85 0.95-0.98 <0.001
 Measurements per year 1.13 0.02 5.98 1.09-1.18 <0.001
D. Neutrophils 1500 – 1900/mm3 (equivalent to amber result)
 Patient on clozapine 1.86 0.58 1.99 1.00-3.43 0.05
 Sex (female) 1.70 0.49 1.85 0.97-3.00 0.09
 Average age at risk 0.96 0.01 −3.70 0.94-0.98 <0.001
 Measurements per year 1.12 0.03 4.62 1.06-1.17 <0.001
  1. A) n = 587, 89 cases. B) n = 587, 37 cases. C) n = 587, 80 cases. D) n = 587, 52 cases