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Table 1 Overview of previous reviews

From: Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis

  First author Title Year of publication Design Type of SSRI assessed Information sources No. of trials No. of patients Published protocol Assessment of adverse events Assessment of risk of bias
Reviews concluding that SSRIs have beneficial effect on major depressive disorder Gibbons et al. Benefits From Antidepressants: Synthesis of 6-Week Patient-Level Outcomes From Double-blind Placebo-Controlled Randomized Trials of Fluoxetine and Venlafaxine 2012 Patient level meta-analysis Flouxetine Eli Lilly and Co 16 3595 No No No
Undurraga et al. Randomized, Placebo-Controlled Trials of Antidepressants for Acute Major Depression: Thirty-Year Meta-Analytic Review 2011 Systematic review Fluoxetine, sertraline, paroxetine, citalopram, escitalopram Medline, CINAH Library, Cochrane Library, PsycINFO 51 5285 No No Only publication bias
Wilson et al. Antidepressants Versus Placebo for the Depressed Elderly 2001 Cochrane review Fluoxetine PsycLIT, MEDLINE, EMBASE, LILACS, CINAHL, SIGLE, Psyndex, National Research Register, Dissertation Abstracts International 2 365 Yes No Only allocation concealment
Aroll et al. Antidepressants versus placebo for depression in primary care (Review) 2009 Cochrane review Sertraline, escitalopram, citalopram CCDANCTR 4 707 Yes Yes Only allocation concealment (QRS)
Reviews concluding that SSRIs have no effect on mild to moderat depression but have beneficial effect on severe depression Fournier et al. Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis 2010 Patient level meta-analysis Paroxetine PubMed, PsycINFO, Cochrane Library 3 240 No No No
Khan et al. Severity of Depression and Response to Antidepressants and Placebo: An Analysis of the Food and Drug Administration Database 2002 Systematic review Fluoxetine, sertraline, paroxetine FDA 18 Unclear No No No
Reviews concluding that SSRIs have questionable effect on major depressive disorder Turner et al. Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy 2008 Systematic review Fluoxetine, sertraline, paroxetine, citalopram, escitalopram FDA, PubMed, Cochrane Library 38 Unclear No No Only publication bias
Kirsch et al. Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration 2008 Systematic review Fluoxetine, sertraline, paroxetine, citalopram FDA, PubMed 21 1708 No No Only publication bias
Reviews not showing anything about the effects of SSRIs on major depressive disorder Moncrieff et al. Active Placebos Versus Antidepressants for Depression (Review) 2012 Cochrane review No SSRIs studied, only TCAs CCDANCTR    Yes