| First author | Title | Year of publication | Design | Type of SSRI assessed | Information sources | No. of trials | No. of patients | Published protocol | Assessment of adverse events | Assessment of risk of bias |
---|---|---|---|---|---|---|---|---|---|---|---|
Reviews concluding that SSRIs have beneficial effect on major depressive disorder | Gibbons et al. | Benefits From Antidepressants: Synthesis of 6-Week Patient-Level Outcomes From Double-blind Placebo-Controlled Randomized Trials of Fluoxetine and Venlafaxine | 2012 | Patient level meta-analysis | Flouxetine | Eli Lilly and Co | 16 | 3595 | No | No | No |
Undurraga et al. | Randomized, Placebo-Controlled Trials of Antidepressants for Acute Major Depression: Thirty-Year Meta-Analytic Review | 2011 | Systematic review | Fluoxetine, sertraline, paroxetine, citalopram, escitalopram | Medline, CINAH Library, Cochrane Library, PsycINFO | 51 | 5285 | No | No | Only publication bias | |
Wilson et al. | Antidepressants Versus Placebo for the Depressed Elderly | 2001 | Cochrane review | Fluoxetine | PsycLIT, MEDLINE, EMBASE, LILACS, CINAHL, SIGLE, Psyndex, National Research Register, Dissertation Abstracts International | 2 | 365 | Yes | No | Only allocation concealment | |
Aroll et al. | Antidepressants versus placebo for depression in primary care (Review) | 2009 | Cochrane review | Sertraline, escitalopram, citalopram | CCDANCTR | 4 | 707 | Yes | Yes | Only allocation concealment (QRS) | |
Reviews concluding that SSRIs have no effect on mild to moderat depression but have beneficial effect on severe depression | Fournier et al. | Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis | 2010 | Patient level meta-analysis | Paroxetine | PubMed, PsycINFO, Cochrane Library | 3 | 240 | No | No | No |
Khan et al. | Severity of Depression and Response to Antidepressants and Placebo: An Analysis of the Food and Drug Administration Database | 2002 | Systematic review | Fluoxetine, sertraline, paroxetine | FDA | 18 | Unclear | No | No | No | |
Reviews concluding that SSRIs have questionable effect on major depressive disorder | Turner et al. | Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy | 2008 | Systematic review | Fluoxetine, sertraline, paroxetine, citalopram, escitalopram | FDA, PubMed, Cochrane Library | 38 | Unclear | No | No | Only publication bias |
Kirsch et al. | Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration | 2008 | Systematic review | Fluoxetine, sertraline, paroxetine, citalopram | FDA, PubMed | 21 | 1708 | No | No | Only publication bias | |
Reviews not showing anything about the effects of SSRIs on major depressive disorder | Moncrieff et al. | Active Placebos Versus Antidepressants for Depression (Review) | 2012 | Cochrane review | No SSRIs studied, only TCAs | CCDANCTR | Â | Â | Yes | Â | Â |