Skip to main content

Table 1 Overview of previous reviews

From: Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis

 

First author

Title

Year of publication

Design

Type of SSRI assessed

Information sources

No. of trials

No. of patients

Published protocol

Assessment of adverse events

Assessment of risk of bias

Reviews concluding that SSRIs have beneficial effect on major depressive disorder

Gibbons et al.

Benefits From Antidepressants: Synthesis of 6-Week Patient-Level Outcomes From Double-blind Placebo-Controlled Randomized Trials of Fluoxetine and Venlafaxine

2012

Patient level meta-analysis

Flouxetine

Eli Lilly and Co

16

3595

No

No

No

Undurraga et al.

Randomized, Placebo-Controlled Trials of Antidepressants for Acute Major Depression: Thirty-Year Meta-Analytic Review

2011

Systematic review

Fluoxetine, sertraline, paroxetine, citalopram, escitalopram

Medline, CINAH Library, Cochrane Library, PsycINFO

51

5285

No

No

Only publication bias

Wilson et al.

Antidepressants Versus Placebo for the Depressed Elderly

2001

Cochrane review

Fluoxetine

PsycLIT, MEDLINE, EMBASE, LILACS, CINAHL, SIGLE, Psyndex, National Research Register, Dissertation Abstracts International

2

365

Yes

No

Only allocation concealment

Aroll et al.

Antidepressants versus placebo for depression in primary care (Review)

2009

Cochrane review

Sertraline, escitalopram, citalopram

CCDANCTR

4

707

Yes

Yes

Only allocation concealment (QRS)

Reviews concluding that SSRIs have no effect on mild to moderat depression but have beneficial effect on severe depression

Fournier et al.

Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis

2010

Patient level meta-analysis

Paroxetine

PubMed, PsycINFO, Cochrane Library

3

240

No

No

No

Khan et al.

Severity of Depression and Response to Antidepressants and Placebo: An Analysis of the Food and Drug Administration Database

2002

Systematic review

Fluoxetine, sertraline, paroxetine

FDA

18

Unclear

No

No

No

Reviews concluding that SSRIs have questionable effect on major depressive disorder

Turner et al.

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

2008

Systematic review

Fluoxetine, sertraline, paroxetine, citalopram, escitalopram

FDA, PubMed, Cochrane Library

38

Unclear

No

No

Only publication bias

Kirsch et al.

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

2008

Systematic review

Fluoxetine, sertraline, paroxetine, citalopram

FDA, PubMed

21

1708

No

No

Only publication bias

Reviews not showing anything about the effects of SSRIs on major depressive disorder

Moncrieff et al.

Active Placebos Versus Antidepressants for Depression (Review)

2012

Cochrane review

No SSRIs studied, only TCAs

CCDANCTR

  

Yes

 Â