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Table 1 Definitions of treatment-resistance

From: Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review

Study Chlorpromazine dose and trial length Number of trials necessary Minimum length of illness Minimum severity score Specify symptoms Clozapine prescription Responsive to clozapine Inability to live independently Prospective confirmation
28 “Therapeutic doses”
6 weeks
2     x    
29 “Adequate”
8 weeks
2   CGI ≥ 4 >4 on 1+ specified PANSS item     
17 400–600
4–6 weeks
2 5 years BPRS > 45 >4 on 2+ specified BPRS items    x  
18 400–600
4–6 weeks
2 5 years BPRS > 45 >4 on 2+ specified BPRS items    x  
27 NICE algorithm    CGI < 4   x    
30 400 mg
4 weeks
2   CGI > 4 One of specified BPRS items     
33 400 mg
4 weeks
2   CGI ≥ 4 One of specified BPRS items x    
34 “sufficient duration” “several”   May score 5–7     x  
32 “optimal clinical requirements” 3 Continuous for 2 years      x  
35 400 mg
4 weeks
2   CGI ≥ 4 One of specified BPRS items x    
36 “sufficient duration” “several”       x  
31 “sufficient duration” “several”       x  
37 1000 mg
6 weeks
3   BPRS > 45
CGI > 4
>4 on 2+ specified BPRS items x x   
38 1000 mg
8 weeks
3        
39 750 mg
6 weeks
3 Continuous for 2 years GAS < 40     x  
40 4–6 weeks 2        <30% decrease in PANSS
41 Kane criteria      inclusive inclusive   
42 Therapeutic doses
6 weeks
2        
43 750 mg
6 weeks
3 2 years BPRS > 45
CGI > 4