Table 2 Definitions of treatment-responsiveness
Study | Consistent good response to antipsychotics | Remission allowing discharge | Remission sustained over long period | Minimum severity before treatment | Minimum improvement | Maximum severity after treatment | Relapse when medication discontinued | Prospective confirmation | Other |
|---|---|---|---|---|---|---|---|---|---|
28 | >50% decrease in BPRS/PANSS | ||||||||
29 | x | ||||||||
17 | 6 months | x | ≤3 PANSS item scores; ≤3 BPRS item scores; ≤2 SAPS/SANS item scores | ||||||
18 | 6 months | x | ≤3 PANSS item scores; ≤3 BPRS item scores; ≤2 SAPS/SANS item scores | ||||||
27 | At most mildly ill (CGI) | ||||||||
30 | x | CGI > 4 | |||||||
33 | x | CGI > 4 | No psychotic symptoms | ||||||
34 | x | May score 1–4 | |||||||
32 | x | at least 1 admission | “full or partial remission” | ||||||
35 | x | CGI > 4 | No psychotic symptoms | ||||||
36 | x | ||||||||
31 | x | ||||||||
37 | 20% decrease in BPRS total | CGI rating ≤3 or BPRS score ≤ 35 | |||||||
38 | x | CGI rating of “very/much improved” | 12 weeks haloperidol < 30 mg | ||||||
39 | x | at least 1 admission | “full or partial remission” | CGI rating ≤3 or BPRS score ≤ 30 | x | x | |||
40 | >30% decrease in PANSS | x | |||||||
41 | “at most mild” | ||||||||
42 | x | ||||||||
43 | x | at least 1 admission | BPRS score ≤ 30 CGI rating <3 | x |