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Table 2 Definitions of treatment-responsiveness

From: Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review

Study Consistent good response to antipsychotics Remission allowing discharge Remission sustained over long period Minimum severity before treatment Minimum improvement Maximum severity after treatment Relapse when medication discontinued Prospective confirmation Other
28      >50% decrease in BPRS/PANSS     
29          x
17    6 months   x ≤3 PANSS item scores;
≤3 BPRS item scores;
≤2 SAPS/SANS item scores
   
18    6 months   x ≤3 PANSS item scores;
≤3 BPRS item scores;
≤2 SAPS/SANS item scores
   
27       At most mildly ill (CGI)    
30    x CGI > 4      
33    x CGI > 4   No psychotic symptoms    
34   x   May score 1–4      
32 x    at least 1 admission “full or partial remission”     
35    x CGI > 4   No psychotic symptoms    
36          x
31   x        
37      20% decrease in BPRS total CGI rating ≤3 or BPRS score ≤ 35    
38   x    CGI rating of “very/much improved”    12 weeks haloperidol < 30 mg  
39 x    at least 1 admission “full or partial remission” CGI rating ≤3 or BPRS score ≤ 30 x   x
40      >30% decrease in PANSS    x  
41       “at most mild”    
42          x
43 x    at least 1 admission   BPRS score ≤ 30
CGI rating <3
x