Fig. 1

Summary of Frequently Reported, Bothersome, or Clinically Important Adverse Events Reported by Patients and Physicians.^a. EPS, extrapyramidal symptoms; MDD, major depressive disorder; TEAE, treatment-emergent adverse event.^a “Frequent” refers to the overall frequency of report for either patient type or for psychiatrists and refers to TEAEs mentioned by ≥50% of patients or those described as “frequent” by psychiatrists; “Bothersome” refers to the report of a TEAE as bothersome by ≥30% of either patient type or as “most” bothersome by ≥20% of either patient type and for psychiatrists as “most bothersome” by 2 of the 4 psychiatrists; “Important” refers to TEAEs identified as “clinically important” by 2 of the 4 psychiatrists. ^b In addition, the following AEs were listed as clinically important by ≥2 physicians: neutropenia, hyperglycemia, hyperlipidemia, QT prolongation, seizures (major medical), hypotension, and metabolic syndrome