Skip to main content

Table 2 Frequency, bother, and most bothersome atypical antipsychotic AEs reported by patients with MDD

From: Assessing the burden of treatment-emergent adverse events associated with atypical antipsychotic medications

 

MDD, n (%)

(n = 25)

AE Categories

Frequency

Bother

Most Bothersomea

Cognitive issues

23 (92)

18 (72)

13 (52)

Weight changes

20 (80)

Weight gain and/or increased appetite

16 (64)

11 (44)

8 (32)

 Weight loss and/or decreased appetite

5 (20)

0

0

Somnolence/sedation

19 (76)

Need to sleep/excessive sleep/excessive sleepiness

19 (76)

9 (36)

7 (28)

 Zombie-like/out of it

5 (20)

2 (8)

1 (4)

Low energy

14 (56)

8 (32)

7 (28)

EPS

13 (52)

5 (20)

3 (12)

Anxietyb

12 (48)

6 (24)

4 (16)

 Mental anxiety

6 (24)

2 (8)

2 (8)

 Physical anxiety

8 (32)

1 (4)

0

 Social anxiety

0

0

0

Sexual function

12 (48)

 Increased sexual desire/activities

1 (4)

1 (4)

0

 Reduced sexual desire or performance

11 (44)

5 (20)

2 (8)

Anticholinergic-related dryness

12 (48)

 Dry eyes

3 (12)

0

0

 Dry mouth

9 (36)

3 (12)

1 (4)

 Dry skin

2 (8)

2 (8)

0

Disequilibrium

11 (44)

3 (12)

0

Insomnia

9 (36)

3 (12)

2 (8)

Restlessness/akathisia

9 (36)

5 (20)

2 (8)

Flat/restricted affect

8 (32)

7 (28)

6 (24)

Anger/aggression

8 (32)

5 (20)

3 (12)

Irritability

7 (28)

6 (24)

4 (16)

Depressive symptoms

6 (24)

6 (24)

4 (16)

Hypomania

5 (20)

4 (16)

2 (8)

Social withdrawal

5 (20)

2 (8)

2 (8)

Bowel/digestive system changes

5 (20)

 Constipation

1 (4)

1 (4)

0

 Diarrhea

3 (12)

1 (4)

0

 Nausea/vomiting

2 (8)

0

0

Cardiovascular

4 (16)

 Hypertension

2 (8)

1 (4)

0

 Hypotension

1 (4)

0

0

 QT prolongation/skipped heartbeat

1 (4)

1 (4)

 

Visual problems

3 (12)

2 (8)

0

Abnormal blood/laboratory test levels

3 (12)

 Anemia

0

0

0

 Hyperglycemia

1 (4)

1 (4)

1 (4)

Hyperlipidemia

2 (8)

2 (8)

0

Hormonal

2 (8)

2 (8)

0

Pain

2 (8)

1 (4)

1 (4)

Other c

2 (8)

1 (4)

0

Major medical (hypothyroidism)

2 (8)

0

0

Major medical (diabetes)

0

0

0

Major medical (seizures)

0

0

0

Increased schizophrenia positive symptoms

0

0

0

  1. Abbreviations: EPS extrapyramidal symptoms, MDD major depressive disorder, QT time between the start of the Q wave and the end of the T wave in the heart’s electrical cycle
  2. a The top 5 AEs most frequently reported as most bothersome are highlighted in bold
  3. b Anxiety is reported as the sum of the participants who endorsed any of the anxiety subcodes and also accounts for participants who reported “anxiety” without noting a subcode
  4. c The category of “other” was created to represent select symptoms reported by 2 or fewer participants that were also not reported as most bothersome, most clinically important, or an AE of specific interest