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Table 2 Frequency, bother, and most bothersome atypical antipsychotic AEs reported by patients with MDD

From: Assessing the burden of treatment-emergent adverse events associated with atypical antipsychotic medications

  MDD, n (%)
(n = 25)
AE Categories Frequency Bother Most Bothersomea
Cognitive issues 23 (92) 18 (72) 13 (52)
Weight changes 20 (80)
Weight gain and/or increased appetite 16 (64) 11 (44) 8 (32)
 Weight loss and/or decreased appetite 5 (20) 0 0
Somnolence/sedation 19 (76)
Need to sleep/excessive sleep/excessive sleepiness 19 (76) 9 (36) 7 (28)
 Zombie-like/out of it 5 (20) 2 (8) 1 (4)
Low energy 14 (56) 8 (32) 7 (28)
EPS 13 (52) 5 (20) 3 (12)
Anxietyb 12 (48) 6 (24) 4 (16)
 Mental anxiety 6 (24) 2 (8) 2 (8)
 Physical anxiety 8 (32) 1 (4) 0
 Social anxiety 0 0 0
Sexual function 12 (48)
 Increased sexual desire/activities 1 (4) 1 (4) 0
 Reduced sexual desire or performance 11 (44) 5 (20) 2 (8)
Anticholinergic-related dryness 12 (48)
 Dry eyes 3 (12) 0 0
 Dry mouth 9 (36) 3 (12) 1 (4)
 Dry skin 2 (8) 2 (8) 0
Disequilibrium 11 (44) 3 (12) 0
Insomnia 9 (36) 3 (12) 2 (8)
Restlessness/akathisia 9 (36) 5 (20) 2 (8)
Flat/restricted affect 8 (32) 7 (28) 6 (24)
Anger/aggression 8 (32) 5 (20) 3 (12)
Irritability 7 (28) 6 (24) 4 (16)
Depressive symptoms 6 (24) 6 (24) 4 (16)
Hypomania 5 (20) 4 (16) 2 (8)
Social withdrawal 5 (20) 2 (8) 2 (8)
Bowel/digestive system changes 5 (20)
 Constipation 1 (4) 1 (4) 0
 Diarrhea 3 (12) 1 (4) 0
 Nausea/vomiting 2 (8) 0 0
Cardiovascular 4 (16)
 Hypertension 2 (8) 1 (4) 0
 Hypotension 1 (4) 0 0
 QT prolongation/skipped heartbeat 1 (4) 1 (4)  
Visual problems 3 (12) 2 (8) 0
Abnormal blood/laboratory test levels 3 (12)
 Anemia 0 0 0
 Hyperglycemia 1 (4) 1 (4) 1 (4)
Hyperlipidemia 2 (8) 2 (8) 0
Hormonal 2 (8) 2 (8) 0
Pain 2 (8) 1 (4) 1 (4)
Other c 2 (8) 1 (4) 0
Major medical (hypothyroidism) 2 (8) 0 0
Major medical (diabetes) 0 0 0
Major medical (seizures) 0 0 0
Increased schizophrenia positive symptoms 0 0 0
  1. Abbreviations: EPS extrapyramidal symptoms, MDD major depressive disorder, QT time between the start of the Q wave and the end of the T wave in the heart’s electrical cycle
  2. a The top 5 AEs most frequently reported as most bothersome are highlighted in bold
  3. b Anxiety is reported as the sum of the participants who endorsed any of the anxiety subcodes and also accounts for participants who reported “anxiety” without noting a subcode
  4. c The category of “other” was created to represent select symptoms reported by 2 or fewer participants that were also not reported as most bothersome, most clinically important, or an AE of specific interest