MDD, n (%) (n = 25) | |||
---|---|---|---|
AE Categories | Frequency | Bother | Most Bothersomea |
Cognitive issues | 23 (92) | 18 (72) | 13 (52) |
Weight changes | 20 (80) | – | – |
Weight gain and/or increased appetite | 16 (64) | 11 (44) | 8 (32) |
Weight loss and/or decreased appetite | 5 (20) | 0 | 0 |
Somnolence/sedation | 19 (76) | – | – |
Need to sleep/excessive sleep/excessive sleepiness | 19 (76) | 9 (36) | 7 (28) |
Zombie-like/out of it | 5 (20) | 2 (8) | 1 (4) |
Low energy | 14 (56) | 8 (32) | 7 (28) |
EPS | 13 (52) | 5 (20) | 3 (12) |
Anxietyb | 12 (48) | 6 (24) | 4 (16) |
Mental anxiety | 6 (24) | 2 (8) | 2 (8) |
Physical anxiety | 8 (32) | 1 (4) | 0 |
Social anxiety | 0 | 0 | 0 |
Sexual function | 12 (48) | – | – |
Increased sexual desire/activities | 1 (4) | 1 (4) | 0 |
Reduced sexual desire or performance | 11 (44) | 5 (20) | 2 (8) |
Anticholinergic-related dryness | 12 (48) | – | – |
Dry eyes | 3 (12) | 0 | 0 |
Dry mouth | 9 (36) | 3 (12) | 1 (4) |
Dry skin | 2 (8) | 2 (8) | 0 |
Disequilibrium | 11 (44) | 3 (12) | 0 |
Insomnia | 9 (36) | 3 (12) | 2 (8) |
Restlessness/akathisia | 9 (36) | 5 (20) | 2 (8) |
Flat/restricted affect | 8 (32) | 7 (28) | 6 (24) |
Anger/aggression | 8 (32) | 5 (20) | 3 (12) |
Irritability | 7 (28) | 6 (24) | 4 (16) |
Depressive symptoms | 6 (24) | 6 (24) | 4 (16) |
Hypomania | 5 (20) | 4 (16) | 2 (8) |
Social withdrawal | 5 (20) | 2 (8) | 2 (8) |
Bowel/digestive system changes | 5 (20) | – | – |
Constipation | 1 (4) | 1 (4) | 0 |
Diarrhea | 3 (12) | 1 (4) | 0 |
Nausea/vomiting | 2 (8) | 0 | 0 |
Cardiovascular | 4 (16) | – | – |
Hypertension | 2 (8) | 1 (4) | 0 |
Hypotension | 1 (4) | 0 | 0 |
QT prolongation/skipped heartbeat | 1 (4) | 1 (4) | |
Visual problems | 3 (12) | 2 (8) | 0 |
Abnormal blood/laboratory test levels | 3 (12) | – | – |
Anemia | 0 | 0 | 0 |
Hyperglycemia | 1 (4) | 1 (4) | 1 (4) |
Hyperlipidemia | 2 (8) | 2 (8) | 0 |
Hormonal | 2 (8) | 2 (8) | 0 |
Pain | 2 (8) | 1 (4) | 1 (4) |
Other c | 2 (8) | 1 (4) | 0 |
Major medical (hypothyroidism) | 2 (8) | 0 | 0 |
Major medical (diabetes) | 0 | 0 | 0 |
Major medical (seizures) | 0 | 0 | 0 |
Increased schizophrenia positive symptoms | 0 | 0 | 0 |