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Table 2 Predictors of course of MDD – Cox proportional hazard models, univariate analysis

From: Childhood neglect predicts the course of major depression in a tertiary care sample: a follow-up study

Predictor at entrya

Probability of recovery or remission

N = 119

Risk of recurrences

N = 65

HR

95% CI

P value

HR

95% CI

P value

Sociodemographic

 Age

0.991

0.972–1.010

0.34

0.975

0.947–1.004

0.09

 Gender – female

1.42

0.81–2.49

0.23

2.15

0.74–6.26

0.16

 Marital status – single, separated, divorced or widowed

0.52

0.32–0.85

0.009

1.58

0.70–3.54

0.27

 Education – Graduate from high school or less

0.82

0.50–1.33

0.42

1.09

0.50–2.41

0.82

 Occupation – not working

0.65

0.36–1.31

0.26

0.74

0.28–1.97

0.54

Clinical

 Age at onset of MDD

0.992

0.972–1.014

0.49

0.935

0.888–0.985

0.01

 Length of MDD

0.997

0.976–1.017

0.75

1.013

0.981–1.045

0.43

 Length of index MDE – chronic

0.45

0.27–0.75

0.002

0.41

0.15-1.09

0.07

Severity of index MDE

 Moderate

0.99

0.53–1.85

0.98

1.06

0.39–2.90

0.90

 Severe

0.60

0.60–1.40

0.24

0.90

0.21–3.85

0.89

Number of previous MDEs ≥ 3

0.93

0.57–1.51

0.76

5.28

1.95–14.3

0.001

Comorbid anxiety disorder

0.62

0.38–1.01

0.06

0.76

0.34–1.67

0.49

Severe personality disorder

0.68

0.29–1.58

0.37

1.37

0.41–4.63

0.61

History of suicide attempts

0.97

0.59–1.61

0.91

3.29

1.39–7.78

0.007

Number of chronic medical conditions

0.949

0.838–1.074

0.403

1.12

0.93–1.36

0.24

Family history of mood disorder in first degree relatives

1.04

0.63–1.72

0.87

1.61

0.68–3.80

0.28

History of childhood maltreatment:

 Emotional abuse

0.93

0.57–1.52

0.77

1.73

0.75–4.02

0.20

 Physical abuse

1.10

0.67–1.81

0.70

1.49

0.67–3.28

0.33

 Sexual abuse

0.84

0.50–1.41

0.50

1.02

0.44–2.38

0.96

 Emotional neglect

0.88

0.53–1.45

0.62

3.81

1.31–11.10

0.01

 Physical neglect

0.48

0.24–0.94

0.03

2.74

1.06–7.05

0.04

Number of Residual symptoms after remission from index MDE

-

-

-

0.989

0.775–1.26

0.93

 Baseline QIDS score

0.96

0.90–1.03

0.29

0.99

0.88–1.11

0.81

 Length of follow-up

0.99

0.97–1.01

0.40

0.99

0.95–1.03

0.67

  1. Legend: MDE major depressive episode, MDD major depressive disorder, QIDS quick inventory of depressive symptomatology aReference categories: Gender: male; Marital status: married or common-law; Education: College diploma or University degree; Occupation: working; Length of index MDE: <2 years; Severity of index MDE: mild; Number of previous MDEs: <3; Comorbid anxiety disorder: absent; Severe personality disorder: absent; History of suicide attempts: absent; Family history of mood disorder in first degree relative: absent; Childhood maltreatment: absent
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BMC Psychiatry

ISSN: 1471-244X

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