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Table 6 Association between individual risk factors for QT-related arrhythmias and TdP, and pharmacological class of antipsychotics

From: Clinicians’ adherence to clinical practice guidelines for cardiac function monitoring during antipsychotic treatment: a retrospective report on 434 patients with severe mental illness

  Pharmacological class of antipsychotics   
Factor First generation Second generation χ 2 P-value
Presence of comorbid somatic illnesses 191 (51.3) 476 (48.8) 0.7 0.4
Presence of cardiac comorbidities 17 (4.6) 34 (3.5) 0.9 0.35
Presence of vascular comorbidities 37 (9.9) 107 (11.0) 0.3 0.6
Use of pharmacological treatments determining QT prolongation during AP therapy 316 (84.9) 744 (76.3) 11.9 0.001
  1. AP antipsychotic
  2. ECG electrocardiogram