TY - JOUR AU - Cattane, Nadia AU - Rossi, Roberta AU - Lanfredi, Mariangela AU - Cattaneo, Annamaria PY - 2017 DA - 2017/06/15 TI - Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms JO - BMC Psychiatry SP - 221 VL - 17 IS - 1 AB - According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability. SN - 1471-244X UR - https://doi.org/10.1186/s12888-017-1383-2 DO - 10.1186/s12888-017-1383-2 ID - Cattane2017 ER -