Table 1 Characteristics of published cases associating psoriasis and antipsychotic treatment
From: Antipsychotic-associated psoriatic rash – a case report
Author [Reference] | No. of cases | Sex | Age | Psychiatric diagnosis | Antipsychotic treatment | Diagnostic assessment of skin condition | Possible effect of antipsychotic treatment | Comments |
|---|---|---|---|---|---|---|---|---|
Ascari-Raccagni et al. [22] | 1 | Female | 52 | Schizophrenia (subtype not specified) | Olanzapine | Dermatologist | Exacerbation of chronic large plague psoriasis | Dramatic worsening of psoriasis two weeks after initiation of olanzapine treatment. Cyclosporin treatment was initiated. Following course of disease is not described. |
Latini et al. [23] | 2 | male | 38 | Psychosis with schizophrenic symptoms | Olanzapine | Unknown | Exacerbation of a pre-existing mild psoriasis | Known large plaque psoriasis from the age of 14. Worsening of psoriatic lesions when olanzapine treatment was initiated. Lesions bettered when olanzapine was discontinued and cyclosporine treatment was initiated. Lesions reappeared when olanzapine was reinitiated 6 months later. |
male | 28 | Psychosis | Olanzapine | Psychiatrist | Triggering of psoriasis in a patient with familial history of psoriasis | Family history of psoriasis but no clinical manifestations of psoriasis before initiation of olanzapine treatment. Lesions appeared 20 days after initiation of olanzapine. Lesions cleared one month after discontinuation of olanzapine. Lesions was treated with topical treatment with salicylic acid and clobetasol propionate. |