Table 4 Spearman rank correlation analysis between 5HTR2A mRNA levels and scores on psychometric scales in patients with schizophrenic disorder during the administration of antipsychotics
Group of patients | Treated with haloperidol | Treated with olanzapine | ||
|---|---|---|---|---|
Indicator of peripheral biogenic amine | 5HTR2A mRNA levels Before treatment | 5HTR2A mRNA levels Before treatment | ||
Scores of psychometric scales: | 0.524* | 0.653** | ||
Administration of antipsychotic | Before treatment | Total PANSS | ||
Positive PANSS | 0.114 | 0.035 | ||
Negative PANSS | 0.237 | 0.329 | ||
General psychopathology PANSS | 0.239 | 0.217 | ||
CGI-S | 0.030 | 0.033 | ||
Day 14 | Total PANSS | −0.018 | 0.686** | |
Positive PANSS | 0.033 | 0.323 | ||
Negative PANSS | 0.080 | 0.332 | ||
General psychopathology PANSS | 0.011 | 0.379* | ||
CGI-S | 0.067 | 0.338 | ||
Day 28 | Total PANSS | 0.061 | 0.715** | |
Positive PANSS | −0.092 | 0.466* | ||
Negative PANSS | −0.031 | 0.411* | ||
General psychopathology PANSS | 0.146 | 0.392* | ||
CGI-S | −0.095 | 0.402* | ||