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Table 3 Psychiatric comorbidities at enrollment for long-acting injectable antipsychotic therapy vs oral antipsychotic therapy cohortsa

From: The Research and Evaluation of Antipsychotic Treatment in Community Behavioral Health Organizations, Outcomes (REACH-OUT) study: real-world clinical practice in schizophrenia

  LAI APT  
  Total
n = 599
New Users
n = 214
Continuous Users
n = 385
Oral APT
n = 281
Age when first hospitalized for symptoms of diagnosis, years
n 480 164 316 180
 Mean (SD) 24.2 (8.35) 24.1 (8.10) 24.3 (8.49) 26.2 (10.24)
P value (LAI APT vs oral APT) 0.020 0.034 0.033  
Time from first hospitalization to enrollment, years
n 471 160 311 173
 Mean (SD) 16.9 (12.11) 14.8 (11.94) 17.9 (12.08) 14.5 (11.39)
P value (LAI APT vs oral APT) 0.025 0.813 0.002  
Age when first diagnosed with schizophrenia or bipolar I, years
n 287 91 196 105
 Mean (SD) 25.9 (9.66) 25.3 (9.38) 26.1 (9.80) 29.1 (13.34)
P value (LAI APT vs oral APT) 0.022 0.020 0.042  
Time from diagnosis to enrollment, years
n 275 86 189 102
 Mean (SD) 15.0 (12.63) 12.2 (11.37) 16.3 (13.00) 11.9 (13.47)
P value (LAI APT vs oral APT) 0.041 0.890 0.008  
Age at first experience of symptoms, years
n 475 164 311 196
 Mean (SD) 22.3 (8.25) 21.9 (8.02) 22.5 (8.38) 23.9 (10.17)
P value (LAI APT vs oral APT) 0.048 0.033 0.107  
Time from first experience of symptoms to enrollment, years
n 464 159 305 190
 Mean (SD) 18.4 (12.26) 17.0 (12.14) 19.1 (12.28) 17.2 (12.41)
P value (LAI APT vs oral APT) 0.269 0.875 0.098  
Any psychiatric hospitalization prior to enrollment
n 533 184 349 250
n (%) 118 (22.1) 59 (32.1) 59 (16.9) 55 (22.0)
P value (LAI APT vs oral APT) 1.000 0.018 0.140  
Time from the most recent psychiatric hospitalization to enrollment, days
n 118 59 59 54
 Mean (SD) 97.7 (139.32) 65.7 (48.13) 129.7 (186.42) 61.8 (43.91)
P value (LAI APT vs oral APT) 0.012 0.658 0.008  
Any all-cause hospitalization prior to enrollment
n 533 184 349 250
n (%) 131 (24.6) 68 (37.0) 63 (18.1) 65 (26.0)
P value (LAI APT vs oral APT) 0.718 0.012 0.019  
Time from the most recent all-cause hospitalization to enrollment, days
n 131 68 63 63
 Mean (SD) 96.1 (133.62) 67.4 (50.56) 127.0 (181.11) 65.5 (45.95)
P value (LAI APT vs oral APT) 0.020 0.828 0.011  
Any psychiatric ED visit prior to enrollment
n 495 166 329 229
n (%) 62 (12.5) 31 (18.7) 31 (9.4) 34 (14.8)
P value (LAI APT vs oral APT) 0.410 0.343 0.058  
Any all-cause ED visit prior to enrollment
n 495 166 329 229
n (%) 85 (17.2) 41 (24.7) 44 (13.4) 41 (17.9)
P value (LAI APT vs oral APT) 0.830 0.104 0.153  
  1. APT antipsychotic therapy, ED emergency department, LAI long-acting injectable (includes paliperidone palmitate long-acting injectable and risperidone long-acting injectable), SD standard deviation
  2. aAll subjects with schizophrenia