The SyBil-AA real-time fMRI neurofeedback study: protocol of a single-blind randomized controlled trial in alcohol use disorder

Table 1 Schedule of measurements conducted in the study

Measurement	S^a	T0^a	MRI1^a	MRI2^a	MRI3^a	FU1/2^b	FU3^a
Sociodemographic information		X
Structured Clinical Interview (SKID – I)	X
Drinking Assessment Interview (Form 90)		X
Blood sample (AUD-related markers)	X						X
Urine sample (pregnancy, drugs)	X
Current medication	X					X^c	X^c
Current smoking behavior		X^c	X^c	X^c	X^c	X^c	X^c
Breath alcohol test							X
Current drug use						X^c	X^c
Incentive Conflict Task		X
Clinical & Personality Questionnaires
Edinburgh Inventory of Handedness	X
Beck Depression Inventory		X
State Trait Anxiety Inventory		X
Behavioral Inhibition/Approach System		X
Barratt Impulsiveness Scale		X
Fagerstrøm Test of Nicotine Dependence		X
Alcohol-Related Questionnaires
Quick Drinking Assessment Interview (Form 90-AQ)						X	X
Alcohol Dependence Scale		X
Alcohol Abstinence Self-Efficacy Scale		X			X		X
German Inventory of Drinking Situations		X
Obsessive Compulsive Drinking Scale		X			X		X
Alcohol Urge Questionnaire		X			X		X
Craving-Automatized-Scale-Alcohol		X			X		X
MRI
Anatomical image (MPRAGE)			X	X	X
Resting state			X	X	X
Neurofeedback			X	X	X
Transfer run			X		X
Craving (visual analog scale) pre & post scanning			X	X	X
Perceived control over NFB (visual analog scale)			X	X	X

S screening assessment, T0 baseline assessment, MRI rtfMRI scanning days, FU monthly follow-up. ^aface-to-face; ^bvia telephone; ^cself-reported (if unclear)

ISSN: 1471-244X