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Table 1 Characteristics of included trials

From: The effect of CBT and its modifications for relapse prevention in major depressive disorder: a systematic review and meta-analysis

Study ID Pre randomization /eligibility Patients Interventions
Author Year Condition Previous episodes Criteria used to measure relapse Previous pharmacology interventions N Agea Male (N/%) Previous episodesa % on ADM at baseline Mean age of first onseta Groups (n/dropouts) Form of intervention N(Number of sessions, frequency, Mean duration + boost sessions) Length of Follow-Up(months)
Bockting 2005 recurrent MDD, in remission for 10 weeks - 2 years 2 + recent episodes in the previous 5 years SCID-I NR 187 44.7/9.5 46/27 3.5/3.8 51 28.4/12.5 CBT:97/16 group 8,weekly,2 h 24
Control(TAU):90/6   
Bondolfi 2010 recurrent MDD, in remission for 3 + months 3 + episodes (2 in the past 5 years and at least one in the past 2 years) SCID a history antidepressants treatment but off medication for 3 + months before enrolment. 60 47.5(24–66) 17/28 4(3–14) 30 24.5(8–55) MBCT:31/4 group 8,weekly,2 h + 4 sessions each 3 months 14
Control(TAU):29/1   
Fava 1994 primary MDD, in full remission NR RDC-defined MDE successfully response to antidepressant drugs according to a standardized protocol 40 43.7/2.3 16/40 NR 100 NR CBT:20/0 individual 10,every other week,40 min 24
Control(PLA):20/0   
Fava 1998 MDD, in full remission for 10 week + 3 or 3 + episodes RDC-defined MDE successfully response to antidepressant drugs according to a standardized protocol. 40 46.1/3.7 13/32.5 3.6/0.8 100 NR CBT:20/0 individual 10,every other week,30 min 24
Control(PLA):20/0   
Godfrin 2010 MDD, in remission for 8 + weeks 3 or 3 + episodes DSM-IV diagnosis of MDE No special 106 45.7/10.5 20/19 NR 76.4 29.8/10.2 MBCT:52/18 group 8,weekly, 2.75 h + homework exercises (meditation practices) for 45 + min/d 14
Control(TAU):54/12   
Hollandare 2013 MDD, in partial remission 1 + episodes in the previous 5 years SCID No special 84 45.3/12.8 13/15 5.96/9.1 50 NR CBT:42/10 individual 16 internet modules + general e-mails for 10 weeks 24
Control(PLA)::42/7   
Kuyken 2008 recurrent MDD, in full or partial remission 3 or 3 + episodes SCID on a continuing dose of m-ADM for 6 + months 123 49.2/11.2 29/24 6.4/3.0 100 26.2/12.1 MBCT-TS:61/9 group 8,weekly,2 h + 4 sessions 15
m-ADM:62/10   
kuyken 2015 recurrent MDD, in full or partial remission 3 or 3 + episodes SCID on a continuing dose of m-ADM for 6 + months 424 49.5/12.5 99/23 46% 6 + 100 24.9/12.4 MBCT-TS:212/23 group 8,weekly, 2.25 h + 4 refresher sessions/3 months 24
m-ADM:212/18   
Ma and Teasdale 2004 MDD, in remission for 12 + weeks 2 or 2 + episodes in the previous 5 years modeled on the SCID a history antidepressants treatment but off medication for 3 + months before enrolment. 75 44.5/9.0 18/24 3/2.0 100 30.6/12.4 MBCT:37/6 group 8,weekly, 2.75 h + homework exercises 13
Control(TAU):38/1   
Paykel 1999 MDD, in remission for 2–18 months residual symptoms DSM-III-R criteria for MDD for at least 1 month AND Minimum symptom score all on a history antidepressants treatment 158 43.4/10.5 80/51 37% 3 + 100 NR CBT:80/19 individual 16 sessions over 20 weeks + 2 sessions 6 and 14 weeks later 15.8
Control(PLA):78/12   
Segal 2010 MDD, in remission for 7+ months 3 + episodes 16 + on the HRSD-17 assessed twice then criteria for MDD measured with SCID all on a history antidepressants treatment 54 44.1/11 31/37 4.7/2.3 55 31/11.6 MBCT:26/5 group 8,weekly,2 h + option 1 h/month mindfulness mediation class 18
m-ADM:28/7   
Stangier 2013 MDD, in full remission 3 or 3 + episodes DSM-IV diagnosis of MDE (LIFE) NR 180 48.6/11.6 50/27.8 7.4/8.3 74.8 30.9/12.4 Maintenance CBT: 90/15 individual 16,NR,50 min 12
Manualized psychoeducation: 90/31 individual 16,NR,20 min
Teasdale 2000 MDD, in remission(0-24 months) 3 + episodes (2 in the past 5 years and at least one in the past 2 years) SCID a history antidepressants treatment but off medication for 3 + months before enrolment. 145 43.3/10.3 35/24 3.3/3.0 100 26.8/10.2 MBCT:76/13 group 8,weekly,2 h + 4 more sessions over trial duration 12
Control(TAU):69/0   
Teismann 2014 MDD, in partial remission NR SCID No special 60 47.1/11.8 17/28 22.45% 5 + 40 NR CBT:31/2 group 11,weekly,90 min 12
WL:29/5   
Wilkinson 2009 MDD, in remission for 2 + months NR MADRS score of 10 + at 6/12 months Received antidepressant medication 45 74.0/7.3 17/38 3.0/1.9 100 NR CBT:22/4 group 8,NR,90 min 12
Control(PLA):23/5   
Williams 2014 MDD, in remission for 8+ weeks 3 or 3 + episodes SCID NR 164 43.4/12 76/28 77% 5 + 44 21.3/10.7 MBCT:108/9 group individual pre class interview + 8,weekly,2 h + follow-up classes taking place 6 weeks and 6 months in the follow-up 12
Control(TAU):56/3   
  1. Note:
  2. a Mean/SD, Median(range)
  3. CBT cognitive behavioral therapy, CPE cognitive psychological education, MBCT mindfulness-based cognitive therapy, MBCT-TS MBCT with support to taper or discontinue antidepressant treatment, TAU treatment as usual, m-ADM Maintenance antidepressant medication, WL wait-list, PLA (psychological or pill) placebo
  4. Criteria used to measure relapse:
  5. DSM Diagnostic Statistical Manual, LIFE Longitudinal Interval Follow-up Evaluation, MDD MDD Disorder, MDE MDD Episode, RDC Research Diagnostic Criteria, SCID Structured Clinical Interview for DSM Disorders, MADRS Montgomery–Asberg Depression Rating Scale, HRSD Hampton Roads Sanitation District