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Table 1 Demographic data and baseline clinical characteristics

From: Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial

 

CRT group (n = 16)

TAU group (n = 15)

  
 

Mean

SD

Mean

SD

t or χ2

P

Sex (male/female)

10/6

 

9/6

 

χ2 = 0.02

0.59

Age (years)

36.1

7.7

37.4

11.0

t = − 0.39

0.70

Handedness (right/left)

16/0

 

13/2

 

χ2 = 2.28

0.23

Years of education

14.3

2.4

13.0

2.0

t = 1.69

0.10

Years from onset of schizophrenia

12.1

7.8

13.9

13.2

t = −0.47

0.65

Number of hospitalizations

1.0

1.2

2.1

1.9

t = − 2.00

0.056

JART

102.6

11.8

97.8

12.2

t = 1.10

0.28

Drugs

 Mean dosage of antipsychoticsa

440.3

265.1

680.3

530.9

t = −1.61

0.12

 Mean dosage of anticholinergicsb

0.75

1.65

1.30

1.51

t = −0.97

0.34

PANSS

 Positive symptoms

14.8

4.9

14.3

4.2

t = 0.26

0.80

 Negative symptoms

20.7

4.4

20.6

7.2

t = 0.04

0.97

 General psychopathology

39.6

7.8

41.5

10.5

t = −0.57

0.57

LASMI

 Interpersonal relations

11.1

3.9

11.5

7.9

t = −2.13

0.83

 Work skills

10.6

3.4

12.6

5.7

t = −1.22

0.23

BACS (z-score)

 Verbal memory

−1.8

1.0

−2.0

1.1

t = 0.56

0.58

 Working memory

−1.3

1.2

−1.3

1.2

t = −0.18

0.86

 Motor speed

−2.4

1.4

−2.8

1.6

t = 0.76

0.45

 Verbal fluency

−1.4

0.8

−0.9

0.8

t = − 1.68

0.10

 Attention and speed of information processing

−1.6

0.8

−2.1

0.9

t = 1.45

0.16

 Executive functions

−0.4

2.3

−1.1

1.6

t = 0.97

0.34

 Composite score

−1.5

0.9

−1.7

0.9

t = 0.63

0.53

  1. Abbreviations: BACS Brief Assessment of Cognition in Schizophrenia, CRT cognitive remediation therapy, JART National Adult Reading Test, Japanese Version, LASMI Life Assessment Scale for the Mentally Ill, PANSS Positive and Negative Syndrome Scale, SD standard deviation, TAU treatment as usual
  2. aChlorpromazine-equivalent dose (mg/day)
  3. bBiperiden-equivalent dose (mg/day)